Price range: $268.00 through $328.00
Background:
This gene encodes a protein that belongs to the MAP kinase kinase kinase (MAPKKK) family of protein kinases. The protein contains ankyrin repeat, protein kinase and serine-rich domains and is thought to play a role in cardiac physiology. [provided by RefSeq, Sep 2012],
| Size | 50μL/100μL |
| Target | TNNI3K |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | 104kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; IHC 1:100-1:300; ELISA 1:10000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human TNNI3K. AA range:301-350 |
| Specificity | TNNI3K Polyclonal Antibody detects endogenous levels of TNNI3K protein. |
| Gene Name | TNNI3K |
| Protein Name | Serine/threonine-protein kinase TNNI3K |
| Other Name | TNNI3K; / CARK; / Serine/threonine-protein kinase TNNI3K; / Cardiac ankyrin repeat kinase; / Cardiac troponin I-interacting kinase; / TNNI3-interacting kinase |
| Species | Human |
| Gene ID | 51086 |
| Uniprot | Q59H18, |
| Species.1 | Mouse |
| Gene ID.1 | 435766 |
| Uniprot.1 | Q5GIG6, |
| Species.2 | Rat |
| Gene ID.2 | 295531 |
| Uniprot.2 | Q7TQP6 |
| Cellular Localization | Nucleus . Cytoplasm . Expressed at lower levels in the cytoplasm. |
| Tissue Expression | Highly expressed in both adult and fetal heart. |
| Signaling_pathway | |
| Research Areas | |
| Function | Catalytic activity:ATP + a protein = ADP + a phosphoprotein.,Catalytic activity:GTP + beta-L-fucose 1-phosphate = diphosphate + GDP-L-fucose.,cofactor:Magnesium.,Function:Catalyzes the formation of GDP-L-fucose from GTP and L-fucose-1-phosphate. Functions as a salvage pathway to reutilize L-fucose arising from the turnover of glycoproteins and glycolipids.,Function:May play a role in cardiac physiology.,PTM:Autophosphorylated.,similarity:Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 10 ANK repeats.,subcellular location:Expressed at lower levels in the cytoplasm.,subunit:Interacts with TNNI3, ACTC, ACTA1, MYBPC3, AIP, BABP3 and HADHB.,tissue specificity:Expressed in many tissues.,tissue specificity:Highly expressed in both adult and fetal heart., |
