Toca 1 rabbit pAb
Ucallm_WP8269-50
Price range: $268.00 through $328.00
Product details
Background:
Specifications
| Size | 50μL/100μL |
| Target | FNBP1L |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 67kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human Toca 1 |
| Specificity | This antibody detects endogenous levels of Toca 1 at Human, Mouse,Rat |
| Gene Name | FNBP1L C1orf39 TOCA1 |
| Protein Name | Formin-binding protein 1-like (Transducer of Cdc42-dependent actin assembly protein 1) (Toca-1) |
| Other Name | |
| Species | Human |
| Gene ID | 54874 |
| Uniprot | Q5T0N5, |
| Species.1 | Mouse |
| Gene ID.1 | 214459 |
| Uniprot.1 | Q8K012, |
| Species.2 | Rat |
| Gene ID.2 | 310839 |
| Uniprot.2 | Q2HWF0 |
| Cellular Localization | Cytoplasm . Cytoplasm, cytoskeleton . Cytoplasm, cell cortex . Cytoplasmic vesicle . Cell membrane; Peripheral membrane protein; Cytoplasmic side . |
| Tissue Expression | |
| Signaling_pathway | |
| Research Areas | |
| Function | Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. May bind to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promote membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by activating the WASL/N-WASP-WASPIP/WIP complex, the predominant form of WASL/N-WASP in cells. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Essential for autophagy of intracellular bacterial pathogens. |
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