SKU: WP2747 Categories: ,

TP4A3 Polyclonal Antibody

Price range: $268.00 through $328.00

SKU: WP2747-100
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Product details

Background:

protein tyrosine phosphatase type IVA, member 3(PTP4A3) Homo sapiens This gene encodes a member of the protein-tyrosine phosphatase family. Protein tyrosine phosphatases are cell signaling molecules that play regulatory roles in a variety of cellular processes. Studies of this class of protein tyrosine phosphatase in mice demonstrates that they are prenylated in vivo, suggesting their association with cell plasma membrane. The encoded protein may enhance cell proliferation, and overexpression of this gene has been implicated in tumor metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013],

Specifications

Size50μL/100μL
TargetTP4A3
ReactivityHuman, Mouse
ApplicationsWB, ELISA
MW(Calculated)
MW(Observed)19kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-2000; ELISA 1:5000-20000
FormulationLiquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from human protein . at AA range: 40-120
SpecificityTP4A3 Polyclonal Antibody detects endogenous levels of protein.
Gene NamePTP4A3 PRL3
Protein NameProtein tyrosine phosphatase type IVA 3 (PRL-R) (Protein-tyrosine phosphatase 4a3) (Protein-tyrosine phosphatase of regenerating liver 3) (PRL-3)
Other Name
SpeciesHuman
Gene ID11156
UniprotO75365,
Species.1Mouse
Gene ID.1
Uniprot.1Q9D658
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationCell membrane . Early endosome .
Tissue ExpressionMainly expressed in cardiomyocytes and skeletal muscle; also found in pancreas. Consistently overexpressed in colon cancer metastasis.
Signaling_pathway
Research Areas
FunctionAlternative products:Additional isoforms seem to exist,Catalytic activity:Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.,Disease:Significantly overexpressed in liver metastasis of colorectal cancer.,enzyme regulation:Inhibited by sodium orthovanadate and peroxovanadium compounds, and by pentamidine.,Function:Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II.,PTM:Farnesylated. Farnesylation is required for membrane targeting.,similarity:Belongs to the protein-tyrosine phosphatase family.,similarity:Contains 1 tyrosine-protein phosphatase domain.,subunit:Interacts with tubulin.,tissue specificity:Mainly expressed in cardiomyocytes and skeletal muscle; also found in pancreas. Consistently overexpressed in colon cancer metastasis.,
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