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TPH1 Polyclonal Antibody
Ucallm_WP14829-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes a member of the aromatic amino acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene have been associated with an elevated risk for a variety of diseases and disorders, including schizophrenia, somatic anxiety, anger-related traits, bipolar disorder, suicidal behavior, addictions, and others.[provided by RefSeq, Apr 2009],
Specifications
| Size | 50μL/100μL |
| Target | Tryptophan Hydroxylase |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 51kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:20000; Not yet tested in other applications. / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human Tryptophan Hydroxylase. AA range:26-75 |
| Specificity | TPH1 Polyclonal Antibody detects endogenous levels of TPH1 protein. |
| Gene Name | TPH1 |
| Protein Name | Tryptophan 5-hydroxylase 1 |
| Other Name | TPH1; / TPH; / TPRH; / TRPH; / Tryptophan 5-hydroxylase 1; / Tryptophan 5-monooxygenase 1 |
| Species | Human |
| Gene ID | 7166 |
| Uniprot | P17752, |
| Species.1 | Mouse |
| Gene ID.1 | 21990 |
| Uniprot.1 | P17532, |
| Species.2 | Rat |
| Gene ID.2 | 24848 |
| Uniprot.2 | P09810 |
| Cellular Localization | cytosol,neuron projection, |
| Tissue Expression | [Isoform 2]: Seems to be less widely expressed than isoform 1. |
| Signaling_pathway | |
| Research Areas | >>Tryptophan metabolism; / >>Folate biosynthesis; / >>Metabolic pathways; / >>Serotonergic synapse |
| Function | Catalytic activity:L-tryptophan + tetrahydrobiopterin + O(2) = 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin.,cofactor:Fe(2+) ion.,pathway:Aromatic compound metabolism; serotonin biosynthesis; serotonin from L-tryptophan: step 1/2.,similarity:Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.,similarity:Contains 1 ACT domain.,subunit:Multimer of identical subunits.,tissue specificity:Isoform 2 seems to be less widely expressed than isoform 1., |
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