TPH2 Polyclonal Antibody
Ucallm_WP14831-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes a member of the pterin-dependent aromatic acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene may be associated with psychiatric diseases such as bipolar affective disorder and major depression. [provided by RefSeq, Feb 2016],
Specifications
| Size | 50μL/100μL |
| Target | TPH2 |
| Reactivity | Human, Mouse, Rat, Monkey |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 56kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; ELISA 1:40000; Not yet tested in other applications. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human TPH2. AA range:4-53 |
| Specificity | TPH2 Polyclonal Antibody detects endogenous levels of TPH2 protein. |
| Gene Name | TPH2 |
| Protein Name | Tryptophan 5-hydroxylase 2 |
| Other Name | TPH2; / NTPH; / Tryptophan 5-hydroxylase 2; / Neuronal tryptophan hydroxylase; / Tryptophan 5-monooxygenase 2 |
| Species | Human |
| Gene ID | 121278 |
| Uniprot | Q8IWU9, |
| Species.1 | Mouse |
| Gene ID.1 | 216343 |
| Uniprot.1 | Q8CGV2, |
| Species.2 | Rat |
| Gene ID.2 | 317675 |
| Uniprot.2 | Q8CGU9 |
| Cellular Localization | cytosol,neuron projection, |
| Tissue Expression | Brain specific. |
| Signaling_pathway | |
| Research Areas | >>Tryptophan metabolism; / >>Folate biosynthesis; / >>Metabolic pathways; / >>Serotonergic synapse |
| Function | Catalytic activity:L-tryptophan + tetrahydrobiopterin + O(2) = 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin.,cofactor:Fe(2+) ion.,Disease:Genetic variation in TPH2 may influence susceptibility to major depressive disorder (MDD) [MIM:608516].,pathway:Aromatic compound metabolism; serotonin biosynthesis; serotonin from L-tryptophan: step 1/2.,similarity:Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.,similarity:Contains 1 ACT domain.,tissue specificity:Brain specific., |
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