TPPP rabbit pAb
Ucallm_WP17840-50
Price range: $268.00 through $328.00
Product details
Background:
Specifications
| Size | 50μL/100μL |
| Target | TPPP |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 24kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human TPPP |
| Specificity | This antibody detects endogenous levels of TPPP at Human, Mouse,Rat |
| Gene Name | TPPP TPPP1 |
| Protein Name | TPPP |
| Other Name | Tubulin polymerization-promoting protein; / TPPP; / 25 kDa brain-specific protein; / TPPP/p25; / p24; / p25-alpha |
| Species | Human |
| Gene ID | 11076 |
| Uniprot | O94811, |
| Species.1 | Mouse |
| Gene ID.1 | 72948 |
| Uniprot.1 | Q7TQD2 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Golgi outpost . Cytoplasm, cytoskeleton, microtubule organizing center . Cytoplasm, cytoskeleton . Nucleus . Cytoplasm, cytoskeleton, spindle . Specifically localizes to the postsynaptic Golgi apparatus region, also named Golgi outpost, which shapes dendrite morphology by functioning as sites of acentrosomal microtubule nucleation (By similarity). Mainly localizes to the cytoskeleton (PubMed:18028908). Also found in the nucleus; however, nuclear localization is unclear and requires additional evidences (PubMed:18028908). Localizes to glial Lewy bodies in the brains of individuals with synucleinopathies (PubMed:15590652, PubMed:17027006). During mitosis, colocalizes with LIMK2 at the mitotic spindle (PubMed:22328514). . |
| Tissue Expression | Widely expressed. |
| Signaling_pathway | |
| Research Areas | |
| Function | Function:Promotes in vitro the polymerization of tubulin into double-walled tubules and polymorphic aggregates or bundled stabilized microtubules blocks. When overexpressed, inhibits mitotic spindle assembly and nuclear envelope breakdown, apparently without affecting other cellular events.,PTM:Phosphorylated by TPK II. Poor substrate for GSK3.,similarity:Belongs to the TPPP family.,subunit:May form dimers. Binds tubulin; binding is inhibited by GTP. Interacts with GSK3.,tissue specificity:Widely expressed., |
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