Product details
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TRAF3IP2 rabbit pAb
Ucallm_WP6709-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | TRAF3IP2 |
| Reactivity | Human |
| Applications | WB |
| MW(Calculated) | 63kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human TRAF3IP2 |
| Specificity | This antibody detects endogenous levels of TRAF3IP2 at Human |
| Gene Name | TRAF3IP2 C6orf2 C6orf4 C6orf5 C6orf6 |
| Protein Name | Adapter protein CIKS (Connection to IKK and SAPK/JNK) (Nuclear factor NF-kappa-B activator 1) (ACT1) (TRAF3-interacting protein 2) |
| Other Name | |
| Species | Human |
| Gene ID | 10758 |
| Uniprot | O43734 |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | |
| Tissue Expression | Widely expressed. |
| Signaling_pathway | Cellular Processes >> Cell growth and death >> Cellular senescence;Organismal Systems >> Immune system >> IL-17 signaling pathway |
| Research Areas | |
| Function | E3 ubiquitin ligase that catalyzes 'Lys-63'-linked polyubiquitination of target protein, enhancing protein-protein interaction and cell signaling . Transfers ubiquitin from E2 ubiquitin-conjugating enzyme UBE2V1-UBE2N to substrate protein . Essential adapter molecule in IL17A-mediated signaling . Upon IL17A stimulation, interacts with IL17RA and IL17RC receptor chains through SEFIR domains and catalyzes 'Lys-63'-linked polyubiquitination of TRAF6, leading to TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways . |
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