Tri-Methyllysine Specific Antibody Conjugated Agarose Beads
Ucallm_WT9167B-100
$999.00
Product details
Tri-Methyllysine Specific Antibody Conjugated Agarose Beads is immobilized to beaded agarose via amide linkages. The product could be utilized as an affinity matrix for rapid isolation and purification of proteins or peptides with trimethyl lysine residues.
Specifications
| Target | Tri-Methyllysine |
| Reactivity | Species Independent |
| Application | IAC, IP |
| MW(Calculated) | |
| MW(Observed) | |
| Host Species | |
| Isotype | |
| Conjugate | Agarose Beads |
| Modification | Lysine Trimethylation |
| Modified site | Lys（K） |
| Recommended dilution ratio | |
| Composition | 0.5 mL beaded agarose suspended in 1 mL of glycerol |
| Purification process | |
| Purity | |
| Storage | Product is stable for several weeks at 4°C. For extended storage, store product at -20°C. |
| Stability | Expiration date is one year from date of shipping if stored properly. |
| Clonal | Polyclonal |
| Clone Number | |
| Immunogen | |
| Sequence | |
| Specificity | |
| Gene name | |
| Protein Name | |
| Alternative name | Kme3 |
| Organism-1 | |
| GeneID-1 | |
| SwissProt-1 | |
| Organism-2 | |
| GeneID-2 | |
| SwissProt-2 | |
| Organism-3 | |
| GeneID-3 | |
| SwissProt-3 | |
| Organism-4 | |
| GeneID-4 | |
| SwissProt-4 | |
| Background | Histones undergo a wide range of enzyme-catalyzed post-translational modifications, including acetylation, methylation, phosphorylation and ubiquitination. Lysine trimethylation is a vital epigenetic modification that predominantly occurs on histone lysine residues. It is dynamically regulated by histone methyltransferases and demethylases, and extensively distributed in eukaryotic chromatin.Lysine trimethylation participates in governing chromatin structure remodeling, transcriptional activation or repression, cell cycle regulation, and DNA damage repair. Abnormal trimethylation levels are closely associated with tumorigenesis, developmental disorders, inflammation and neurodegenerative diseases, acting as a pivotal molecular marker for epigenetic research and disease mechanism investigation. |
| Cellular Localization |
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