TRI23 Polyclonal Antibody
Ucallm_WP1166-50
Price range: $268.00 through $328.00
Product details
Background:
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein is also a member of the ADP ribosylation factor family of guanine nucleotide-binding family of proteins. Its carboxy terminus contains an ADP-ribosylation factor domain and a guanine nucleotide binding site, while the amino terminus contains a GTPase activating protein domain which acts on the guanine nucleotide binding site. The protein localizes to lysosomes and the Golgi apparatus. It plays a role in the formation of intracellular transport vesicles, their movement from one compartment to another, and phopholipase D activation. Three alternatively spliced transcript variants for this gene have been described. [provided by RefSeq, Jul 2008],
Specifications
| Size | 50μL/100μL |
| Target | TRI23 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 63kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | TRI23 Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | TRIM23 ARD1 ARFD1 RNF46 |
| Protein Name | E3 ubiquitin-protein ligase TRIM23 (ADP-ribosylation factor domain-containing protein 1) (GTP-binding protein ARD-1) (RING finger protein 46) (Tripartite motif-containing protein 23) |
| Other Name | |
| Species | Human |
| Gene ID | 373 |
| Uniprot | P36406, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q8BGX0, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | P36407 |
| Cellular Localization | Cytoplasm . Endomembrane system . Golgi apparatus membrane . Lysosome membrane . Membrane-associated with the Golgi complex and lysosomal structures. |
| Tissue Expression | Brain, |
| Signaling_pathway | |
| Research Areas | |
| Function | Function:Not known, the C-terminus can act as an allosteric activator of the cholera toxin catalytic subunit.,similarity:Contains 1 B box-type zinc finger.,similarity:Contains 1 RING-type zinc finger.,similarity:In the C-terminal section; belongs to the small GTPase superfamily. Arf family.,subcellular location:Membrane-associated with the Golgi complex and lysosomal structures.,subunit:Interacts with PSCD1., |
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