Product details
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TRIM22 rabbit pAb
Ucallm_WP6487-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | TRIM22 |
| Reactivity | Human |
| Applications | WB |
| MW(Calculated) | 55kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human TRIM22 |
| Specificity | This antibody detects endogenous levels of TRIM22 at Human |
| Gene Name | TRIM22 RNF94 STAF50 |
| Protein Name | E3 ubiquitin-protein ligase TRIM22 (50 kDa-stimulated trans-acting factor) (RING finger protein 94) (Staf-50) (Tripartite motif-containing protein 22) |
| Other Name | |
| Species | Human |
| Gene ID | 10346 |
| Uniprot | Q8IYM9 |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm . Nucleus . Nucleus speckle. Nucleus, Cajal body. Localizes predominantly to the nucleus, found in cytoplasm to some extent. Forms distinct nuclear bodies that undergo dynamic changes during cell cycle progression. Nuclear bodies start to form in the early G0/G1 phase but become speckle-like in the S-phase and completely dispersed in mitosis. 35% of TRIM22 nuclear bodies overlap or are found adjacent to Cajal bodies. |
| Tissue Expression | Strongly expressed in peripheral blood leukocytes, spleen, thymus, and ovary. Expressed at basal levels in other tissues. |
| Signaling_pathway | |
| Research Areas | |
| Function | Interferon-induced antiviral protein involved in cell innate immunity. The antiviral activity could in part be mediated by TRIM22-dependent ubiquitination of viral proteins. Plays a role in restricting the replication of HIV-1, encephalomyocarditis virus (EMCV) and hepatitis B virus (HBV). Acts as a transcriptional repressor of HBV core promoter. May have E3 ubiquitin-protein ligase activity. |
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