Product details
Background:
- Please choose product options by visiting TRPC1 Polyclonal Antibody.
- Please choose product options by visiting TRIOBP rabbit pAb.
- Please choose product options by visiting Trk A (phospho Tyr496) Polyclonal Antibody.
- Please choose product options by visiting TRI44 rabbit pAb.
- Please choose product options by visiting TRI47 rabbit pAb.
TRIM29 rabbit pAb
Ucallm_WP6343-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | TRIM29 |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | 65kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human TRIM29 |
| Specificity | This antibody detects endogenous levels of TRIM29 at Human, Mouse |
| Gene Name | TRIM29 ATDC |
| Protein Name | Tripartite motif-containing protein 29 (Ataxia telangiectasia group D-associated protein) |
| Other Name | |
| Species | Human |
| Gene ID | 23650 |
| Uniprot | Q14134, |
| Species.1 | Mouse |
| Gene ID.1 | 72169 |
| Uniprot.1 | Q8R2Q0 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm . Lysosome . Colocalizes with intermediate filaments. |
| Tissue Expression | Expressed in placenta, prostate and thymus. |
| Signaling_pathway | |
| Research Areas | |
| Function | Plays a crucial role in the regulation of macrophage activation in response to viral or bacterial infections within the respiratory tract. Mechanistically, TRIM29 interacts with IKBKG/NEMO in the lysosome where it induces its 'Lys-48' ubiquitination and subsequent degradation. In turn, the expression of type I interferons and the production of pro-inflammatory cytokines are inhibited. Additionally, induces the 'Lys-48' ubiquitination of STING1 in a similar way, leading to its degradation. |
Please login to post questions
Related products
