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Home/Reagents/Antibody/Primary antibody/Polyclonal Antibody/Rabbit pAb/TRPC1 Polyclonal Antibody
SKU: WP1731 Categories: ,

TRPC1 Polyclonal Antibody

Ucallm_WP1731-50

Price range: $268.00 through $328.00

SKU: WP1731-100
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Product details

Background:

transient receptor potential cation channel subfamily C member 1(TRPC1) Homo sapiens The protein encoded by this gene is a membrane protein that can form a non-selective channel permeable to calcium and other cations. The encoded protein appears to be induced to form channels by a receptor tyrosine kinase-activated phosphatidylinositol second messenger system and also by depletion of intracellular calcium stores. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011],

Specifications

Size50μL/100μL
TargetTRPC1
ReactivityHuman, Mouse, Rat
ApplicationsWB, ELISA
MW(Calculated)
MW(Observed)87kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-2000; ELISA 1:5000-20000
FormulationLiquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from part region of human protein
SpecificityTRPC1 Polyclonal Antibody detects endogenous levels of protein.
Gene NameTRPC1 TRP1
Protein NameShort transient receptor potential channel 1 (TrpC1) (Transient receptor protein 1) (TRP-1)
Other Name
SpeciesHuman
Gene ID7220
UniprotP48995,
Species.1Mouse
Gene ID.1
Uniprot.1Q61056,
Species.2Rat
Gene ID.2
Uniprot.2Q9QX01
Cellular LocalizationMembrane; Multi-pass membrane protein.
Tissue ExpressionSeems to be ubiquitous.
Signaling_pathwayOrganismal Systems >> Nervous system >> Glutamatergic synapse
Research Areas>>Axon guidance; / >>Glutamatergic synapse; / >>Serotonergic synapse; / >>GnRH secretion; / >>Pancreatic secretion
FunctionFunction:Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion.,similarity:Belongs to the transient receptor family. STrpC subfamily.,similarity:Contains 3 ANK repeats.,subunit:Interacts with TRPC3. Interacts with ITPR3. Interacts with MX1 and RNF24.,tissue specificity:Seems to be ubiquitous.,
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