Name: TRPM1 rabbit pAb
SKU: WP7766
Price: 268 USD
Availability: InStock

TRPM1 rabbit pAb

Ucallm_WP7766-50

Price range: $268.00 through $328.00

Size

100μl

50μl

Clear

SKU: WP7766-100

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Product details

Background:

Specifications

Size	50μL/100μL
Target	TRPM1
Reactivity	Human, Mouse, Rat
Applications	WB
MW(Calculated)	176kD
MW(Observed)
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-2000
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	Synthesized peptide derived from human TRPM1
Specificity	This antibody detects endogenous levels of TRPM1 at Human, Mouse,Rat
Gene Name	TRPM1 LTRPC1 MLSN MLSN1
Protein Name	Transient receptor potential cation channel subfamily M member 1 (Long transient receptor potential channel 1) (LTrpC1) (Melastatin-1)
Other Name
Species	Human
Gene ID	4308
Uniprot	Q7Z4N2,
Species.1	Mouse
Gene ID.1	17364
Uniprot.1	Q2TV84,
Species.2	Rat
Gene ID.2	361586
Uniprot.2	Q2WEA5
Cellular Localization	Cell membrane; Multi-pass membrane protein . Endoplasmic reticulum membrane; Multi-pass membrane protein . Cell projection, axon .
Tissue Expression	Expressed in the retina where it localizes to the outer plexiform layer. Specifically, it is expressed in retinal bipolar cells (BPCs) of the ON subtype (PubMed:30027108). Highly expressed in benign melanocytic nevi and diffusely expressed in various in situ melanomas, but not detected in melanoma metastases. Also expressed in melanocytes and pigmented metastatic melanoma cell lines. In melanocytes expression appears to be regulated at the level of transcription and mRNA processing.
Signaling_pathway
Research Areas
Function	Forms nonselective divalent cation-conducting channels which mediate the influx of Na(2+), Ca(2+), Mg(2+), Mn(2+), Ba(2+), and Ni(2+) into the cytoplasm, leading to membrane depolarization . Impermeable to zinc ions . In addition, forms heteromultimeric ion channels with TRPM3 which are permeable for calcium and zinc ions . Essential for the depolarizing photoresponse of retinal ON bipolar cells. It is part of the GRM6 signaling cascade. May play a role in metastasis suppression (By similarity). May act as a spontaneously active, calcium-permeable plasma membrane channel.