SKU: WP3700 Categories: ,

TRPC5 rabbit pAb

Price range: $268.00 through $328.00

SKU: WP3700-100
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Product details

Background:

This gene belongs to the transient receptor family. It encodes one of the seven mammalian TRPC (transient receptor potential channel) proteins. The encoded protein is a multi-pass membrane protein and is thought to form a receptor-activated non-selective calcium permeant cation channel. The protein is active alone or as a heteromultimeric assembly with TRPC1, TRPC3, and TRPC4. It also interacts with multiple proteins including calmodulin, CABP1, enkurin, Na(+)-H+ exchange regulatory factor (NHERF ), interferon-induced GTP-binding protein (MX1), ring finger protein 24 (RNF24), and SEC14 domain and spectrin repeat-containing protein 1 (SESTD1). [provided by RefSeq, May 2010],

Specifications

Size50μL/100μL
TargetTRPC5
ReactivityHuman, Mouse
ApplicationsWB
MW(Calculated)
MW(Observed)105kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-2000
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from human TRPC5 AA range: 828-878
SpecificityThis antibody detects endogenous levels of TRPC5 at Human/Mouse
Gene NameTRPC5 TRP5
Protein NameTRPC5
Other NameShort transient receptor potential channel 5; / TrpC5; / Transient receptor protein 5; / TRP-5; / hTRP-5; / hTRP5
SpeciesHuman
Gene ID7224
UniprotQ9UL62,
Species.1Mouse
Gene ID.122067
Uniprot.1Q9QX29
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationCell membrane; Multi-pass membrane protein .
Tissue ExpressionExpressed in brain with higher levels in fetal brain. Found in cerebellum and occipital pole.
Signaling_pathway
Research Areas>>Axon guidance; / >>GnRH secretion
FunctionFunction:Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Has also been shown to be calcium-selective (By similarity). May also be activated by intracellular calcium store depletion.,similarity:Belongs to the transient receptor family. STrpC subfamily.,similarity:Contains 2 ANK repeats.,subunit:Interacts with NHERF (By similarity). Interacts with MX1 and RNF24.,tissue specificity:Expressed in brain with higher levels in fetal brain.,
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