TRPC5 rabbit pAb
Ucallm_WP3700-50
Price range: $268.00 through $328.00
Product details
Background:
This gene belongs to the transient receptor family. It encodes one of the seven mammalian TRPC (transient receptor potential channel) proteins. The encoded protein is a multi-pass membrane protein and is thought to form a receptor-activated non-selective calcium permeant cation channel. The protein is active alone or as a heteromultimeric assembly with TRPC1, TRPC3, and TRPC4. It also interacts with multiple proteins including calmodulin, CABP1, enkurin, Na(+)-H+ exchange regulatory factor (NHERF ), interferon-induced GTP-binding protein (MX1), ring finger protein 24 (RNF24), and SEC14 domain and spectrin repeat-containing protein 1 (SESTD1). [provided by RefSeq, May 2010],
Specifications
| Size | 50μL/100μL |
| Target | TRPC5 |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | |
| MW(Observed) | 105kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human TRPC5 AA range: 828-878 |
| Specificity | This antibody detects endogenous levels of TRPC5 at Human/Mouse |
| Gene Name | TRPC5 TRP5 |
| Protein Name | TRPC5 |
| Other Name | Short transient receptor potential channel 5; / TrpC5; / Transient receptor protein 5; / TRP-5; / hTRP-5; / hTRP5 |
| Species | Human |
| Gene ID | 7224 |
| Uniprot | Q9UL62, |
| Species.1 | Mouse |
| Gene ID.1 | 22067 |
| Uniprot.1 | Q9QX29 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cell membrane; Multi-pass membrane protein . |
| Tissue Expression | Expressed in brain with higher levels in fetal brain. Found in cerebellum and occipital pole. |
| Signaling_pathway | |
| Research Areas | >>Axon guidance; / >>GnRH secretion |
| Function | Function:Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Has also been shown to be calcium-selective (By similarity). May also be activated by intracellular calcium store depletion.,similarity:Belongs to the transient receptor family. STrpC subfamily.,similarity:Contains 2 ANK repeats.,subunit:Interacts with NHERF (By similarity). Interacts with MX1 and RNF24.,tissue specificity:Expressed in brain with higher levels in fetal brain., |
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