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TRPC1 Polyclonal Antibody
Ucallm_WP1731-50
Price range: $268.00 through $328.00
Product details
Background:
transient receptor potential cation channel subfamily C member 1(TRPC1) Homo sapiens The protein encoded by this gene is a membrane protein that can form a non-selective channel permeable to calcium and other cations. The encoded protein appears to be induced to form channels by a receptor tyrosine kinase-activated phosphatidylinositol second messenger system and also by depletion of intracellular calcium stores. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011],
Specifications
| Size | 50μL/100μL |
| Target | TRPC1 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 87kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | TRPC1 Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | TRPC1 TRP1 |
| Protein Name | Short transient receptor potential channel 1 (TrpC1) (Transient receptor protein 1) (TRP-1) |
| Other Name | |
| Species | Human |
| Gene ID | 7220 |
| Uniprot | P48995, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q61056, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | Q9QX01 |
| Cellular Localization | Membrane; Multi-pass membrane protein. |
| Tissue Expression | Seems to be ubiquitous. |
| Signaling_pathway | Organismal Systems >> Nervous system >> Glutamatergic synapse |
| Research Areas | >>Axon guidance; / >>Glutamatergic synapse; / >>Serotonergic synapse; / >>GnRH secretion; / >>Pancreatic secretion |
| Function | Function:Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion.,similarity:Belongs to the transient receptor family. STrpC subfamily.,similarity:Contains 3 ANK repeats.,subunit:Interacts with TRPC3. Interacts with ITPR3. Interacts with MX1 and RNF24.,tissue specificity:Seems to be ubiquitous., |
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