TRIM3 Polyclonal Antibody
Ucallm_WP14855-50
Price range: $268.00 through $328.00
Product details
Background:
The protein encoded by this gene is a member of the tripartite motif (TRIM) family, also called the 'RING-B-box-coiled-coil' (RBCC) subgroup of RING finger proteins. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to cytoplasmic filaments. It is similar to a rat protein which is a specific partner for the tail domain of myosin V, a class of myosins which are involved in the targeted transport of organelles. The rat protein can also interact with alpha-actinin-4. Thus it is suggested that this human protein may play a role in myosin V-mediated cargo transport. Alternatively spliced transcript variants encoding the same isoform have been identified. [provided by RefSeq, Jul 2008],
Specifications
| Size | 50μL/100μL |
| Target | TRIM3 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 81kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:40000; Not yet tested in other applications. / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human TRIM3. AA range:1-50 |
| Specificity | TRIM3 Polyclonal Antibody detects endogenous levels of TRIM3 protein. |
| Gene Name | TRIM3 |
| Protein Name | Tripartite motif-containing protein 3 |
| Other Name | TRIM3; / BERP; / RNF22; / RNF97; / Tripartite motif-containing protein 3; / Brain-expressed RING finger protein; / RING finger protein 22; / RING finger protein 97 |
| Species | Human |
| Gene ID | 10612 |
| Uniprot | O75382, |
| Species.1 | Mouse |
| Gene ID.1 | 55992 |
| Uniprot.1 | Q9R1R2, |
| Species.2 | Rat |
| Gene ID.2 | 83616 |
| Uniprot.2 | O70277 |
| Cellular Localization | Cytoplasm . Early endosome . Golgi apparatus, trans-Golgi network . Cell projection, dendrite . |
| Tissue Expression | Expressed in brain, heart, uterus and testis. |
| Signaling_pathway | |
| Research Areas | |
| Function | Domain:The interaction with myosin V is dependent upon its NHL repeats, which form a beta-propeller (NHL) domain containing six blades.,similarity:Belongs to the TRIM/RBCC family.,similarity:Contains 1 B box-type zinc finger.,similarity:Contains 1 filamin repeat.,similarity:Contains 1 RING-type zinc finger.,similarity:Contains 6 NHL repeats.,subunit:Associates with myosin V and alpha-actinin-4 (ACTN4).,tissue specificity:Expressed in brain, heart, uterus and testis., |
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