TRIM32 rabbit pAb
Ucallm_WP6133-50
Price range: $268.00 through $328.00
Product details
Background:
Specifications
| Size | 50μL/100μL |
| Target | TRIM32 |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | 72kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human TRIM32 |
| Specificity | This antibody detects endogenous levels of TRIM32 at Human, Mouse |
| Gene Name | TRIM32 HT2A |
| Protein Name | E3 ubiquitin-protein ligase TRIM32 (72 kDa Tat-interacting protein) (Tripartite motif-containing protein 32) (Zinc finger protein HT2A) |
| Other Name | |
| Species | Human |
| Gene ID | 22954 |
| Uniprot | Q13049, |
| Species.1 | Mouse |
| Gene ID.1 | 69807 |
| Uniprot.1 | Q8CH72 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm . Localized in cytoplasmic bodies, often located around the nucleus. . |
| Tissue Expression | Spleen, thymus, prostate, testis, ovary, intestine, colon and skeletal muscle. |
| Signaling_pathway | Genetic Information Processing >> Folding, sorting and degradation >> Ubiquitin mediated proteolysis |
| Research Areas | |
| Function | Has an E3 ubiquitin ligase activity . Ubiquitinates DTNBP1 (dysbindin) and promotes its degradation . May ubiquitinate BBS2 . Ubiquitinates PIAS4/PIASY and promotes its degradation in keratinocytes treated with UVB and TNF-alpha (By similarity). Also acts as a regulator of autophagy by mediating formation of unanchored 'Lys-63'-linked polyubiquitin chains that activate ULK1: interaction with AMBRA1 is required for ULK1 activation .; (Microbial infection) May play a significant role in mediating the biological activity of the HIV-1 Tat protein in vivo . Binds specifically to the activation domain of HIV-1 Tat and can also interact with the HIV-2 and EIAV Tat proteins in vivo . |
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