SKU: WP2846 Categories: ,

TRIP6 Polyclonal Antibody

Price range: $268.00 through $328.00

SKU: WP2846-100
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Product details

Background:

This gene is a member of the zyxin family and encodes a protein with three LIM zinc-binding domains. This protein localizes to focal adhesion sites and along actin stress fibers. Recruitment of this protein to the plasma membrane occurs in a lysophosphatidic acid (LPA)-dependent manner and it regulates LPA-induced cell migration. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008],

Specifications

Size50μL/100μL
TargetTRIP6
ReactivityHuman, Mouse
ApplicationsWB, ELISA
MW(Calculated)
MW(Observed)52kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-2000; ELISA 1:5000-20000
FormulationLiquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from human protein . at AA range: 221-270
SpecificityTRIP6 Polyclonal Antibody detects endogenous levels of protein.
Gene NameTRIP6 OIP1
Protein NameThyroid receptor-interacting protein 6 (TR-interacting protein 6) (TRIP-6) (Opa-interacting protein 1) (OIP-1) (Zyxin-related protein 1) (ZRP-1)
Other Name
SpeciesHuman
Gene ID7205
UniprotQ15654,
Species.1Mouse
Gene ID.1
Uniprot.1Q9Z1Y4
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationCytoplasm, cytoskeleton . Cell junction, focal adhesion . Nucleus . Cytoplasm . Shuttles between nucleus and cytoplasm (PubMed:16624523). Colocalizes with actin (PubMed:10826496). .
Tissue ExpressionAbundantly expressed in kidney, liver and lung. Lower levels in heart, placenta and pancreas. Expressed in colonic epithelial cells. Up-regulated in colonic tumors.
Signaling_pathwayOrganismal Systems >> Immune system >> NOD-like receptor signaling pathway
Research Areas>>NOD-like receptor signaling pathway
FunctionFunction:May relays signals from the cell surface to the nucleus.,similarity:Belongs to the zyxin/ajuba family.,similarity:Contains 1 LIM zinc-binding domain.,similarity:Contains 3 LIM zinc-binding domains.,subunit:Specifically interacts with the ligand binding domain of the thyroid receptor (TR). Requires the presence of thyroid hormone for its interaction. Interacts with PTPN13.,tissue specificity:Abundantly expressed in kidney, liver and lung. Lower levels in heart, placenta and pancreas.,
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