Product details
Background:
- Please choose product options by visiting TRIM2 rabbit pAb.
- Please choose product options by visiting TRIM22 rabbit pAb.
- Please choose product options by visiting TRIM32 rabbit pAb.
- Please choose product options by visiting TRIM27 rabbit pAb.
- Please choose product options by visiting TRIM26 rabbit pAb.
- Please choose product options by visiting TRIM15 rabbit pAb.
TRIM14 rabbit pAb
Ucallm_WP6417-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | TRIM14 |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | 49kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human TRIM14 |
| Specificity | This antibody detects endogenous levels of TRIM14 at Human, Mouse |
| Gene Name | TRIM14 KIAA0129 |
| Protein Name | Tripartite motif-containing protein 14 |
| Other Name | |
| Species | Human |
| Gene ID | 9830 |
| Uniprot | Q14142, |
| Species.1 | Mouse |
| Gene ID.1 | 74735 |
| Uniprot.1 | Q8BVW3 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Mitochondrion outer membrane . Cytoplasmic vesicle, phagosome . |
| Tissue Expression | Highest expression in liver; undetectable in skeletal muscle. |
| Signaling_pathway | |
| Research Areas | |
| Function | Plays an essential role in the innate immune defense against viruses and bacteria . Facilitates the type I IFN response by interacting with MAVS at the outer mitochondria membrane and thereby recruiting NF-kappa-B essential modulator IKBKG/NEMO to the MAVS signalosome, leading to the activation of both the IFN regulatory factor 3/IRF3 and NF-kappa-B pathways . Positively regulates the CGAS-induced type I interferon signaling pathway by stabilizing CGAS and inhibiting its autophagic degradation . Acts as a scaffold between TBK1 and STAT3 to promote phosphorylation of STAT3 and resolve interferon-stimulated gene (ISG) expression . Inhibits the transcriptional activity of SPI1 in a dose-dependent manner (By similarity). |
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