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TRIP10 rabbit pAb
Ucallm_WP6826-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | TRIP10 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 66kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human TRIP10 |
| Specificity | This antibody detects endogenous levels of TRIP10 at Human, Mouse,Rat |
| Gene Name | TRIP10 CIP4 STOT STP |
| Protein Name | Cdc42-interacting protein 4 (Protein Felic) (Salt tolerant protein) (hSTP) (Thyroid receptor-interacting protein 10) (TR-interacting protein 10) (TRIP-10) |
| Other Name | |
| Species | Human |
| Gene ID | 9322 |
| Uniprot | Q15642, |
| Species.1 | Mouse |
| Gene ID.1 | 106628 |
| Uniprot.1 | Q8CJ53, |
| Species.2 | Rat |
| Gene ID.2 | 116717 |
| Uniprot.2 | P97531 |
| Cellular Localization | Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Lysosome. Golgi apparatus. Cell membrane. Cell projection, phagocytic cup. Translocates to the plasma membrane in response to insulin stimulation, and this may require active RHOQ (By similarity). Localizes to cortical regions coincident with F-actin, to lysosomes and to sites of phagocytosis in macrophages. Also localizes to the Golgi, and this requires AKAP9. .; [Isoform 5]: Cytoplasm, perinuclear region. |
| Tissue Expression | Expressed in brain, colon, heart, kidney, liver, lung, megakaryocyte, ovary, pancreas, peripheral blood lymphocytes, placenta, prostate, skeletal muscle, small intestine, spleen, testis, thymus and trachea. |
| Signaling_pathway | Organismal Systems >> Endocrine system >> Insulin signaling pathway |
| Research Areas | |
| Function | Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N-WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells. May be required for the lysosomal retention of FASLG/FASL. |
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