SKU: WP15188 Categories: ,

TRPV3 Polyclonal Antibody

Price range: $268.00 through $328.00

SKU: WP15188-100
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Product details

Background:

transient receptor potential cation channel subfamily V member 3(TRPV3) Homo sapiens This gene product belongs to a family of nonselective cation channels that function in a variety of processes, including temperature sensation and vasoregulation. The thermosensitive members of this family are expressed in subsets of sensory neurons that terminate in the skin, and are activated at distinct physiological temperatures. This channel is activated at temperatures between 22 and 40 degrees C. This gene lies in close proximity to another family member gene on chromosome 17, and the two encoded proteins are thought to associate with each other to form heteromeric channels. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012],

Specifications

Size50μL/100μL
TargetTRPV3
ReactivityHuman, Mouse
ApplicationsWB, IHC, IF, ELISA
MW(Calculated)
MW(Observed)90kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-1:2000; IHC: 1:100-300; ELISA 1:20000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from the Internal region of human TRPV3.at AA range:330-375.
SpecificityTRPV3 Polyclonal Antibody detects endogenous levels of TRPV3 protein.at AA:330-375.
Gene NameTRPV3
Protein NameTransient receptor potential cation channel subfamily V member 3
Other NameTRPV3; / Transient receptor potential cation channel subfamily V member 3; / TrpV3; / Vanilloid receptor-like 3; / VRL-3
SpeciesHuman
Gene ID162514
UniprotQ8NET8,
Species.1Mouse
Gene ID.1246788
Uniprot.1Q8K424
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationMembrane; Multi-pass membrane protein.
Tissue ExpressionAbundantly expressed in CNS. Widely expressed at low levels. Detected in dorsal root ganglion (at protein level). Expressed in the keratinocyte layers of the outer root sheath and, to lesser extent, to the matrix of the hair follicles (at protein level).
Signaling_pathwayOrganismal Systems >> Sensory system >> Inflammatory mediator regulation of TRP channels
Research Areas>>Inflammatory mediator regulation of TRP channels
FunctionFunction:Putative receptor-activated non-selective calcium permeant cation channel. It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures greater than 39 degrees Celsius. Activation exhibits an outward rectification. May associate with TRPV1 and may modulate its activity.,similarity:Belongs to the transient receptor family. TrpV subfamily.,similarity:Contains 3 ANK repeats.,subunit:May form a heteromeric channel with TRPV1. Interacts with TRPV1.,tissue specificity:Abundantly expressed in CNS. Widely expressed at low levels. Detected in dorsal root ganglion (at protein level).,
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