TRY2 Polyclonal Antibody
Ucallm_WP16063-50
Price range: $268.00 through $328.00
Product details
Background:
This gene belongs to the trypsin family of serine proteases and encodes anionic trypsinogen. It is part of a cluster of trypsinogen genes that are located within the T cell receptor beta locus. Enzymes of this family cleave peptide bonds that follow lysine or arginine residues. This protein is found at high levels in pancreatic juice and its upregulation is a characteristic feature of pancreatitis. This protein has also been found to activate pro-urokinase in ovarian tumors, suggesting a function in tumor invasion. In addition, this enzyme is able to cleave across the type II collagen triple helix in rheumatoid arthritis synovitis tissue, potentially participating in the degradation of type II collagen-rich cartilage matrix. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2015],
Specifications
| Size | 50μL/100μL |
| Target | TRY2 |
| Reactivity | Human, Mouse, Rat |
| Applications | IHC, IF, WB |
| MW(Calculated) | |
| MW(Observed) | 27kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:50-200; WB 1:500-2000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human TRY2 |
| Specificity | This antibody detects endogenous levels of human TRY2 |
| Gene Name | PRSS2 TRY2 TRYP2 |
| Protein Name | Trypsin-2 (Anionic trypsinogen) (Serine protease 2) (Trypsin II) |
| Other Name | Trypsin-2; / Anionic trypsinogen; / Serine protease 2; / Trypsin II |
| Species | Human |
| Gene ID | 5645 |
| Uniprot | P07478, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | P07146, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | P00763 |
| Cellular Localization | Secreted, extracellular space. |
| Tissue Expression | Expressed in Paneth cells, at the base of small intestinal crypts. |
| Signaling_pathway | |
| Research Areas | >>Neuroactive ligand-receptor interaction; / >>Pancreatic secretion; / >>Protein digestion and absorption; / >>Influenza A |
| Function | Catalytic activity:Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.,cofactor:Binds 1 calcium ion per subunit.,PTM:Sulfated on tyrosine.,similarity:Belongs to the peptidase S1 family.,similarity:Contains 1 peptidase S1 domain., |
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