Trypsin-1 Polyclonal Antibody
Ucallm_WP14872-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is secreted by the pancreas and cleaved to its active form in the small intestine. It is active on peptide linkages involving the carboxyl group of lysine or arginine. Mutations in this gene are associated with hereditary pancreatitis. This gene and several other trypsinogen genes are localized to the T cell receptor beta locus on chromosome 7. [provided by RefSeq, Jul 2008],
Specifications
| Size | 50μL/100μL |
| Target | Trypsin-1 |
| Reactivity | Human, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 23kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; ELISA 1:10000; Not yet tested in other applications. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human Trypsin-1. AA range:60-109 |
| Specificity | Trypsin-1 Polyclonal Antibody detects endogenous levels of Trypsin-1 protein. |
| Gene Name | PRSS1 |
| Protein Name | Serine protease 1 |
| Other Name | PRSS1; / TRP1; / TRY1; / TRYP1; / Trypsin-1; / Beta-trypsin; / Cationic trypsinogen; / Serine protease 1; / Trypsin I |
| Species | Human |
| Gene ID | 5644 |
| Uniprot | P07477, |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | P00762 |
| Cellular Localization | Secreted, extracellular space. |
| Tissue Expression | Brain,Cajal-Retzius cell,Gastric adenocarcinoma,PCR rescued clones,Prostate, |
| Signaling_pathway | |
| Research Areas | >>Neuroactive ligand-receptor interaction; / >>Pancreatic secretion; / >>Protein digestion and absorption; / >>Influenza A |
| Function | Catalytic activity:Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.,Caution:Tyr-154 was proposed to be phosphorylated (PubMed:8683601) but it has been shown (PubMed:17087724) to be sulfated instead. Phosphate and sulfate groups are similar in mass and size, and this can lead to erroneous interpretation of the results.,cofactor:Binds 1 calcium ion per subunit.,Disease:Defects in PRSS1 are a cause of hereditary pancreatitis (HPC) [MIM:167800]; also known as chronic pancreatitis (CP). HPC is an autosomal dominant disease characterized by the presence of calculi in pancreatic ducts. It causes severe abdominal pain attacks.,Function:Has activity against the synthetic substrates Boc-Phe-Ser-Arg-Mec, Boc-Leu-Thr-Arg-Mec, Boc-Gln-Ala-Arg-Mec and Boc-Val-Pro-Arg-Mec. The single-chain form is more active than the two-chain form against all of these substrates.,mass spectrometry: PubMed:8683601,PTM:Occurs in a single-chain form and a two-chain form, produced by proteolytic cleavage after Arg-122.,similarity:Belongs to the peptidase S1 family.,similarity:Contains 1 peptidase S1 domain., |
Please login to post questions
Related products
