TSHB Polyclonal Antibody
Ucallm_WP2616-50
Price range: $268.00 through $328.00
Product details
Background:
The four human glycoprotein hormones chorionic gonadotropin (CG), luteinizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated noncovalently. The alpha subunits of these hormones are identical, however, their beta chains are unique and confer biological specificity. Thyroid stimulating hormone functions in the control of thyroid structure and metabolism. The protein encoded by this gene is the beta subunit of thyroid stimulating hormone. Mutations in this gene are associated with congenital central and secondary hypothyroidism and Hashimoto's thyroiditis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013],
Specifications
| Size | 50μL/100μL |
| Target | TSHB |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 15kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | TSHB Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | TSHB |
| Protein Name | Thyrotropin subunit beta (Thyroid-stimulating hormone subunit beta) (TSH-B) (TSH-beta) (Thyrotropin beta chain) (Thyrotropin alfa) |
| Other Name | |
| Species | Human |
| Gene ID | 7252 |
| Uniprot | P01222, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | P12656, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | P04652 |
| Cellular Localization | Secreted. |
| Tissue Expression | |
| Signaling_pathway | Human Diseases >> Immune disease >> Autoimmune thyroid disease;Environmental Information Processing >> Signal transduction >> cAMP signaling pathway |
| Research Areas | >>cAMP signaling pathway; / >>Neuroactive ligand-receptor interaction; / >>Thyroid hormone synthesis; / >>Regulation of lipolysis in adipocytes; / >>Autoimmune thyroid disease |
| Function | Function:Indispensable for the control of thyroid structure and metabolism.,online information:Clinical information on Thyrogen,online information:Thyroid-stimulating hormone entry,pharmaceutical:Available under the name Thyrogen (Genzyme). Used in combination with other tests to detect recurring or leftover thyroid cancer cells in patients with a history of certain types of thyroid cancer.,similarity:Belongs to the glycoprotein hormones subunit beta family.,subunit:Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin., |
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