Product details
Background:
- Please choose product options by visiting TWEAKR/FN14 rabbit pAb.
- Please choose product options by visiting TTC19 Polyclonal Antibody.
TTI1 rabbit pAb
Ucallm_WP7569-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | TTI1 |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | 120kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human TTI1 |
| Specificity | This antibody detects endogenous levels of TTI1 at Human, Mouse |
| Gene Name | TTI1 KIAA0406 SMG10 |
| Protein Name | TELO2-interacting protein 1 homolog (Protein SMG10) |
| Other Name | |
| Species | Human |
| Gene ID | 9675 |
| Uniprot | O43156, |
| Species.1 | Mouse |
| Gene ID.1 | 75425 |
| Uniprot.1 | Q91V83 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm . |
| Tissue Expression | Widely expressed. |
| Signaling_pathway | Environmental Information Processing >> Signal transduction >> mTOR signaling pathway |
| Research Areas | |
| Function | Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals. |
Please login to post questions
Related products
