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Home/Reagents/Antibody/Primary antibody/Polyclonal Antibody/Rabbit pAb/TudorSN Polyclonal Antibody
SKU: WP15178 Categories: ,

TudorSN Polyclonal Antibody

Ucallm_WP15178-50

Price range: $268.00 through $328.00

SKU: WP15178-100
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Product details

Background:

This gene encodes a transcriptional co-activator that interacts with the acidic domain of Epstein-Barr virus nuclear antigen 2 (EBNA 2), a transcriptional activator that is required for B-lymphocyte transformation. Other transcription factors that interact with this protein are signal transducers and activators of transcription, STATs. This protein is also thought to be essential for normal cell growth. A similar protein in mammals and other organisms is a component of the RNA-induced silencing complex (RISC). [provided by RefSeq, Jul 2016],

Specifications

Size50μL/100μL
TargetTudorSN
ReactivityHuman, Mouse, Rat
ApplicationsWB, IHC, IF, ELISA
MW(Calculated)
MW(Observed)101kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-1:2000; IHC: 1:100-300; ELISA 1:40000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from the Internal region of human TudorSN.
SpecificityTudorSN Polyclonal Antibody detects endogenous levels of TudorSN protein.
Gene NameSND1
Protein NameStaphylococcal nuclease domain-containing protein 1
Other NameSND1; / TDRD11; / Staphylococcal nuclease domain-containing protein 1; / 100 kDa coactivator; / EBNA2 coactivator p100; / Tudor domain-containing protein 11; / p100 co-activator
SpeciesHuman
Gene ID27044
UniprotQ7KZF4,
Species.1Mouse
Gene ID.156463
Uniprot.1Q78PY7,
Species.2Rat
Gene ID.264635
Uniprot.2Q66X93
Cellular LocalizationCytoplasm . Nucleus . Melanosome . In IL-4 stimulated cells colocalizes with STAT6 in the nucleus (PubMed:12234934). Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). .
Tissue ExpressionUbiquitously expressed.
Signaling_pathway
Research Areas>>Viral carcinogenesis
FunctionFunction:Functions as a bridging factor between STAT6 and the basal transcription factor. Plays a role in PIM1 regulation of MYB activity. Functions as a transcriptional coactivator for the Epstein-Barr virus nuclear antigen 2 (EBNA2).,PTM:Phosphorylated by PIM1 in vitro.,sequence Caution:The frameshift leads to wrong initation.,similarity:Contains 1 Tudor domain.,similarity:Contains 4 TNase-like domains.,subcellular location:In IL-4 stimulated cells colocalizes with STAT6 in the nucleus. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,subunit:Binds to acidic transactivation domain of EBNA2. Interacts with EAV NSP1. Interacts with GTF2E1 and GTF2E2. Forms a ternary complex with STAT6 and POLR2A. Interacts with STAT5.,tissue specificity:Ubiquitously expressed.,
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