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Home/Reagents/Antibody/Primary antibody/Monoclonal Antibody/Mouse mAb/TXNRD2 mouse mAb
SKU: WM0653 Categories: ,

TXNRD2 mouse mAb

Ucallm_WM0653-50

Price range: $268.00 through $328.00

SKU: WM0653-50
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Product details

Background:
thioredoxin reductase 2(TXNRD2) Homo sapiens This gene encodes a member of the class I pyridine nucleotide-disulfide oxidoreductase family. The encoded protein is a selenocysteine-containing flavoenzyme that maintains thioredoxins in a reduced state, thereby playing a key role in regulating the cellular redox environment. Mammals have three related thioredoxin reductases. This gene encodes a mitochondrial form important for scavenging of reactive oxygen species in mitochondria. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Sep 2013],

Specifications

TargetTXNRD2
ReactivityHuman
ApplicationsWB
MW(Calculated)
MW(Observed)56kD
Host SpeciesMouse
Isotype
Conjugate/ModificationUnmodified
Modification
Recommended Dilution RatioWB 1:1000
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
PurificationThe antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
Purity
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
ClonalityMonoclonal
Clone Number17A12
ImmunogenPurified recombinant human TXNRD2 protein fragments expressed in E.coli.
Sequence
SpecificityThis antibody detects endogenous levels of TXNRD2 and does not cross-react with related proteins.
Gene NameTXNRD2
Protein NameThioredoxin reductase 2 mitochondrial
Other NameTXNRD2; / KIAA1652; / TRXR2; / Thioredoxin reductase 2; / mitochondrial; / Selenoprotein Z; / SelZ; / TR-beta; / Thioredoxin reductase TR3
SpeciesHuman
Gene ID-110587
UniprotQ9NNW7
Species.1
Gene ID-2
Uniprot.1
Species.2
Gene ID-3
Uniprot.2
Organism-4
Gene ID-4
SwissProt-4
Backgroundthioredoxin reductase 2(TXNRD2) Homo sapiens This gene encodes a member of the class I pyridine nucleotide-disulfide oxidoreductase family. The encoded protein is a selenocysteine-containing flavoenzyme that maintains thioredoxins in a reduced state, thereby playing a key role in regulating the cellular redox environment. Mammals have three related thioredoxin reductases. This gene encodes a mitochondrial form important for scavenging of reactive oxygen species in mitochondria. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Sep 2013],
Cellular LocalizationMitochondrion .
Tissue ExpressionHighly expressed in the prostate, ovary, liver, testis, uterus, colon and small intestine. Intermediate levels in brain, skeletal muscle, heart and spleen. Low levels in placenta, pancreas, thymus and peripheral blood leukocytes. According to PubMed:10608886, high levels in kidney, whereas according to PubMed:9923614, levels are low. High expression is observed in the adrenal cortex (PubMed:24601690).
Signaling_pathwayHuman Diseases >> Cancer: overview >> Pathways in cancer;Human Diseases >> Cancer: specific types >> Hepatocellular carcinoma
Research Areas>>Selenocompound metabolism; / >>Pathways in cancer; / >>Hepatocellular carcinoma
FunctionCatalytic activity:Thioredoxin + NADP(+) = thioredoxin disulfide + NADPH.,cofactor:FAD.,Function:Maintains thioredoxin in a reduced state. Implicated in the defenses against oxidative stress. May play a role in redox-regulated cell signaling.,miscellaneous:The active site is a redox-active disulfide bond. The selenocysteine residue is essential for enzymatic activity.,sequence Caution:Translated as Sec.,similarity:Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.,subunit:Homodimer.,tissue specificity:Highly expressed in the prostate, ovary, liver, testis, uterus, colon and small intestine. Intermediate levels in brain, skeletal muscle, heart and spleen. Low levels in placenta, pancreas, thymus and peripheral blood leukocytes. According to PubMed:10608886, high levels in kidney, whereas according to PubMed:9923614 levels are low.,
RRID
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