Specifications
| Size | 50μL/100μL |
| Target | ABCG5 |
| Reactivity | Human, Mouse |
| Applications | WB, IF, ELISA |
| MW(Calculated) | 73kD |
| MW(Observed) | 73kD |
| Host Species | Rabbit |
| Isotype | IgG,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Purification | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | RM1826R |
| Immunogen | The specific immunogen used to produce this antibody is proprietary information. |
| Specificity | Endogenous |
| Gene Name | ABCG5 |
| Protein Name | ATP-binding cassette sub-family G member 5 (Sterolin-1) |
| Other Name | |
| Species | Human |
| Gene ID | 64240 |
| Uniprot | Q9H222, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q99PE8, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | Q99PE7 |
| Cellular Localization | Cell membrane; Multi-pass membrane protein . Apical cell membrane; Multi-pass membrane protein . |
| Tissue Expression | Strongly expressed in the liver, lower levels in the small intestine and colon. |
| Signaling_pathway | |
| Research Areas | >>ABC transporters; / >>Fat digestion and absorption; / >>Bile secretion; / >>Cholesterol metabolism |
| Function | Disease:Defects in ABCG5 are a cause of sitosterolemia [MIM:210250]; also known as phytosterolemia or shellfish sterolemia. It is a rare autosomal recessive disorder characterized by increased intestinal absorption of all sterols including cholesterol, plant and shellfish sterols, and decreased biliary excretion of dietary sterols into bile. Sitosterolemia patients have hypercholesterolemia, very high levels of plant sterols in the plasma, and frequently develop tendon and tuberous xanthomas, accelerated atherosclerosis and premature coronary artery disease.,Function:Transporter that appears to play an indispensable role in the selective transport of the dietary cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile.,similarity:Belongs to the ABC transporter family. ABCG (White) subfamily.,similarity:Contains 1 ABC transmembrane type-2 domain.,similarity:Contains 1 ABC transporter domain.,subunit:May form heterodimers with ABCG8 or be tightly coupled to ABCG8 along a pathway regulating diatery-sterol absorption and excretion.,tissue specificity:Strongly expressed in the liver, lower levels in the small intestine and colon., |
