Specifications
| Size | 50μL/100μL |
| Target | ANGPTL3 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | 54kD |
| MW(Observed) | 58kD |
| Host Species | Rabbit |
| Isotype | IgG,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:200-1:1000; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Purification | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | RM1799R |
| Immunogen | The specific immunogen used to produce this antibody is proprietary information. |
| Specificity | Endogenous |
| Gene Name | ANGPTL3 ANGPT5 UNQ153/PRO179 |
| Protein Name | Angiopoietin-related protein 3 |
| Other Name | ANGPTL3; / ANGPT5; / Angiopoietin-related protein 3; / Angiopoietin-5; / ANG-5; / Angiopoietin-like protein 3 |
| Species | Human |
| Gene ID | 27329 |
| Uniprot | Q9Y5C1, |
| Species.1 | Mouse |
| Gene ID.1 | 30924 |
| Uniprot.1 | Q9R182 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Secreted . Cell projection, lamellipodium . Colocalized with HSPG2 and activated ITGB3 on podocytes. . |
| Tissue Expression | Expressed principally in liver. Weakly expressed in kidney. Binds to adipocytes. Increased expression and colocalization with activated ITGB3 in glomeruli of patients with nephrotic syndrome showing effaced podocyte foot processes (at protein level). |
| Signaling_pathway | |
| Research Areas | >>Cholesterol metabolism |
| Function | blood vessel development, vasculature development, glycerol metabolic process, fatty acid metabolic process,phospholipid metabolic process, cell adhesion, cell-matrix adhesion, cell surface receptor linked signal transduction,integrin-mediated signaling pathway, steroid metabolic process, cholesterol metabolic process, phospholipid catabolic process, regulation of catabolic process, positive regulation of catabolic process, regulation of phospholipase activity,negative regulation of phospholipase activity, lipid localization, lipid catabolic process, sterol metabolic process,regulation of lipid metabolic process, alditol metabolic process, organophosphate metabolic process, polyol metabolic process, lipid storage, biological adhesion, regulation of cell migration, positive regulation of cell migration, cell-substrate adhesion, regulation of locomotion, positive regulation of locomotion, homeostatic process, cholesterol homeostasis, negative regulation of catalytic activity, negative regulation of molecular function, cellular lipid catabolic process, regulation of angiogenesis, positive regulation of angiogenesis, positive regulation of lipid metabolic process,blood vessel morphogenesis, artery morphogenesis, chemical homeostasis, regulation of lipid catabolic process,positive regulation of lipid catabolic process, regulation of lipoprotein lipase activity, negative regulation of lipoprotein lipase activity, positive regulation of developmental process, regulation of cell motion, positive regulation of cell motion, regulation of hydrolase activity, negative regulation of hydrolase activity, lipid homeostasis, acylglycerol homeostasis, phospholipid homeostasis, sterol homeostasis, regulation of lipase activity, negative regulation of lipase activity, |
