U-Blot® BAFF hIgG4 Reference Antibody (Tababio)
UcallM
$999.00
Product details
Background：Tabalumab is a humanized IgG4 monoclonal antibody that targets b-cell activating factor (BAFF/Blys/TNFSF13B) , inhibits its binding to b-cell receptors by neutralizing soluble and membrane-bound BAFF, and inhibits its binding to b-cell receptors, thus, it can regulate the activation, proliferation and antibody production of B cells, and has potential value in the treatment of autoimmune diseases. As a BAFF inhibitor developed by Eli Lilly, its mechanism of action focuses on blocking BAFF-mediated b-cell survival signals, reducing abnormal autoantibody production, and reducing the risk of BAFF-mediated apoptosis, in theory, it could be used to treat diseases such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA).
Specifications
| Target | BAFF |
| Reactivity | |
| Applications | Bioactivity-ELISA |
| MW(Calculated) | |
| MW(Observed) | |
| Host Species | Human |
| Isotype | IgG4, |
| Conjugate/Modification | Unconjugated |
| Modification | |
| Recommended Dilution Ratio | |
| Formulation Buffer | Phosphate-buffered solution, pH 7.2-7.4. |
| Source | |
| Purification | |
| Purity | > 95% as determined by SDS-PAGE |
| Storage | Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term.Avoid repeated freeze-thaw. |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | tabalumab |
| Immunogen | |
| Sequence | |
| Specificity | |
| Gene Name | |
| Protein Name | |
| Other Name | TNFSF13B, BLYS, CD257, TALL-1, TALL1, THANK, TNFSF20, TNLG7A, ZTNF4 |
| Species | |
| Gene ID | |
| Uniprot | |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Organism-4 | |
| GeneID-4 | |
| SwissProt-4 | |
| Cellular Localization | |
| Tissue Expression | |
| Signaling_pathway | |
| Research Areas | |
| Function | |
| RRID |
Please login to post questions
Related products
