U-Blot® C17orf96 Polyclonal Antibody
UcallM
$999.00
Product details
Background:CDK8 (Cyclin-Dependent Kinase 8) is a component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. CDK8 phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. Other studies have indicated a role in transcriptional activation in response to hypoxia.
Specifications
| Target | -- |
| Reactivity | Mouse |
| Applications | ChIP; ChIP-Seq; WB |
| MW(Calculated) | 50 kDa |
| Host Species | Rabbit |
| Isotype | IgG |
| Recommended Dilution Ratio | Applications Validated by Active Motif: WB: 1:500 - 1:2,000 dilution |
| Formulation | Purified IgG in 70 mM Tris (pH 8), 105 mM NaCl, 31 mM glycine, 0.07 mM EDTA, 30% glycerol and 0.035% sodium azide. Sodium azide is highly toxic. |
| Purification | Affinity Purified |
| Storage | Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage. |
| Concentration | -- |
| Clonality | Polyclonal |
| Clone Number | -- |
| Immunogen | This antibody was raised against a recombinant protein corresponding to amino acids 59-229 of mouse C17orf96. |
| Specificity | -- |
| Gene Name | -- |
| Other Name | E13, AA409164, AI413509, AW539173, esPRC2p48 |
| Gene ID | -- |
| Cellular Localization | -- |
| Function | -- |
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