Price range: $268.00 through $328.00
Background：
kinesin family member 2C(KIF2C) Homo sapiens This gene encodes a kinesin-like protein that functions as a microtubule-dependent molecular motor. The encoded protein can depolymerize microtubules at the plus end, thereby promoting mitotic chromosome segregation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014],
| Size | 50μL/100μL |
| Target | IL-2Rβ |
| Reactivity | Human |
| Applications | FC, IF |
| MW(Calculated) | |
| MW(Observed) | |
| Host Species | Mouse |
| Isotype | Mouse IgG1/Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IF 1:200-1:1000; FC:1 µg per million cells in 100 µl volume. For optimal results, the reagent should be titrated according to each specific application |
| Formulation | PBS, pH 7.4 |
| Purification | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography. |
| Storage | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Concentration | 0.5mg/ml |
| Clonality | Monoclonal |
| Clone Number | RMMF0110 |
| Immunogen | The specific immunogen used to produce this antibody is proprietary information. |
| Specificity | Endogenous |
| Gene Name | IL2RB |
| Protein Name | Interleukin-2 receptor subunit beta |
| Other Name | IL2RB; / Interleukin-2 receptor subunit beta; / IL-2 receptor subunit beta; / IL-2R subunit beta; / IL-2RB; / High affinity IL-2 receptor subunit beta; / p70-75; / p75; / CD antigen CD122 |
| Species | Human |
| Gene ID | 3560 |
| Uniprot | P14784, |
| Species.1 | Mouse |
| Gene ID.1 | 16185 |
| Uniprot.1 | P16297, |
| Species.2 | Rat |
| Gene ID.2 | 25746 |
| Uniprot.2 | P26896 |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein . |
| Tissue Expression | Lung, |
| Signaling_pathway | Organismal Systems >> Immune system >> Th1 and Th2 cell differentiation;Organismal Systems >> Immune system >> Th17 cell differentiation;Human Diseases >> Cancer: overview >> Pathways in cancer;Human Diseases >> Cancer: overview >> Transcriptional misregulation in cancer;Environmental Information Processing >> Signal transduction >> JAK-STAT signaling pathway;Environmental Information Processing >> Signal transduction >> PI3K-Akt signaling pathway;Environmental Information Processing >> Signaling molecules and interaction >> Cytokine-cytokine receptor interaction;Environmental Information Processing >> Signaling molecules and interaction >> Viral protein interaction with cytokine and cytokine receptor |
| Research Areas | >>Cytokine-cytokine receptor interaction; / >>Viral protein interaction with cytokine and cytokine receptor; / >>Endocytosis; / >>PI3K-Akt signaling pathway; / >>JAK-STAT signaling pathway; / >>Th1 and Th2 cell differentiation; / >>Th17 cell differentiation; / >>Measles; / >>Human T-cell leukemia virus 1 infection; / >>Pathways in cancer; / >>Transcriptional misregulation in cancer |
| Function | Domain:The box 1 motif is required for JAK interaction and/or activation.,Domain:The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.,Function:Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2.,similarity:Belongs to the type I cytokine receptor family. Type 4 subfamily.,similarity:Contains 1 fibronectin type-III domain.,subunit:Non-covalent dimer of an alpha and a beta chains. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta chain), and a low affinity monomer (alpha chain). The high and intermediate affinity forms also associate with a gamma chain. Interacts with SHB upon interleukin stimulation. Interacts with HTLV-1 accessory protein p12I., |
