Name: U-Blot® CD180 Mouse mAb
SKU: WM1893
Price: 268 USD
Availability: InStock

U-Blot® CD180 Mouse mAb

Ucallm_WM1893-50

Price range: $268.00 through $328.00

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50μl

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SKU: WM1893-50

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Product details

Background:CD180 is a cell surface molecule consisting of extracellular leucine-rich repeats (LRR) and a short cytoplasmic tail. The extracellular LRR is associated with a molecule called MD-1 and form the cell surface receptor complex, RP105/MD-1. It belongs to the family of pathogen receptors, Toll-like receptors (TLR). RP105/MD1, by working in concert with TLR4, controls B cell recognition and signaling of lipopolysaccharide (LPS), a membrane constituent of Gram-negative bacteria. [provided by RefSeq, Jul 2008],

Specifications

Target	CD180
Reactivity	Human
Applications	FC, IF
MW(Calculated)
MW(Observed)
Host Species	Mouse
Isotype	Mouse IgG1,Kappa
Conjugate/Modification	Unmodified
Modification
Recommended Dilution Ratio	IF 1:200-1:1000; FC:1 µg per million cells in 100 µl volume. For optimal results, the reagent should be titrated according to each specific application
Formulation	PBS, pH 7.4
Source
Purification	Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
Purity
Storage	Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Concentration	0.5mg/ml
Clonality	Monoclonal
Clone Number	PTF0105
Immunogen	The specific immunogen used to produce this antibody is proprietary information.
Sequence
Specificity	Endogenous
Gene Name	CD180
Protein Name	CD180 antigen
Other Name	CD180; / LY64; / RP105; / CD180 antigen; / Lymphocyte antigen 64; / Radioprotective 105 kDa protein; / CD180
Species	Human
Gene ID	4064
Uniprot	Q99467,
Species.1	Mouse
Gene ID.1	17079
Uniprot.1	Q62192
Species.2
Gene ID.2
Uniprot.2
Organism-4
GeneID-4
SwissProt-4
Cellular Localization	Cell membrane; Single-pass type I membrane protein.
Tissue Expression	Expressed mainly on mature peripherical B cells. Detected in spleen, lymph node and appendix. Not detected in pre-B and -T cells.
Signaling_pathway
Research Areas
Function	Disease:Decreased expression of LY64 has been shown in systemic lupus erythematosus (SLE). The loss of LY64 is associated with B-cell activation and increased disease activity in SLE patients.,Function:May cooperate with MD-1 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) in B-cells. Leads to NF-kappa-B activation. Also involved in the life/death decision of B-cells.,similarity:Belongs to the Toll-like receptor family.,similarity:Contains 17 LRR (leucine-rich) repeats.,subunit:Binds to MD-1.,tissue specificity:Expressed mainly on mature peripherical B cells. Detected in spleen, lymph node and appendix. Not detected in pre-B and -T cells.,
RRID

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U-Blot® CD180 Mouse mAb

Product details

Specifications

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U-Blot® CD180 Mouse mAb

Product details

Specifications

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