Name: U-Blot® CD158b Mouse mAb
SKU: WM1892
Price: 268 USD
Availability: InStock

Product details

Background:Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several " framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the

Specifications

Size	50μL/100μL
Target	CD158b
Reactivity	Human
Applications	FC, IF
MW(Calculated)
MW(Observed)
Host Species	Mouse
Isotype	Mouse IgG2b,Kappa
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	IF 1:200-1:1000; FC:1 µg per million cells in 100 µl volume. For optimal results, the reagent should be titrated according to each specific application
Formulation	PBS, pH 7.4
Purification	Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
Storage	Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Concentration	0.5mg/ml
Clonality	Monoclonal
Clone Number	RMMF0130
Immunogen	The specific immunogen used to produce this antibody is proprietary information.
Specificity	Endogenous
Gene Name	KIR2DL3/KIR2DS2 CD158B1 NKAT6
Protein Name	Killer cell immunoglobulin-like receptor 2DL2 (CD158 antigen-like family member B1) (MHC class I NK cell receptor) (Natural killer-associated transcript 6) (NKAT-6) (p58 natural killer cell receptor clone CL-43) (p58 NK receptor CL-43) (CD antigen CD158b1) Killer cell immunoglobulin-like receptor 2DL3/Killer cell immunoglobulin-like receptor 2DS2
Other Name	KIR2DL3; / CD158B2; / KIRCL23; / NKAT2; / Killer cell immunoglobulin-like receptor 2DL3; / CD158 antigen-like family member B2; / KIR-023GB; / Killer inhibitory receptor cl 2-3; / MHC class I NK cell receptor; / NKAT2a; / NKAT2bNatural killer-associated transcript 2; / NKAT-2; / p58 natural killer cell receptor clone CL-6; / p58 NK receptor CL-6; / p58.2 MHC class-I-specific NK receptor; / CD158b2; / KIR2DS2; / CD158J; / NKAT5; / Killer cell immunoglobulin-like receptor 2DS2
Species	Human
Gene ID	3803;3804;100132285
Uniprot	P43627,P43628,P43631
Species.1
Gene ID.1
Uniprot.1
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Cell membrane; Single-pass type I membrane protein.
Tissue Expression	Natural killer cell
Signaling_pathway	Organismal Systems >> Immune system >> Natural killer cell mediated cytotoxicity;Organismal Systems >> Immune system >> Antigen processing and presentation;Human Diseases >> Immune disease >> Graft-versus-host disease
Research Areas	>>Antigen processing and presentation; / >>Natural killer cell mediated cytotoxicity; / >>Graft-versus-host disease
Function	Function:Receptor on natural killer (NK) cells for HLA-C alleles. Inhibits the activity of NK cells thus preventing cell lysis.,miscellaneous:PubMed:15580659, identified a chromosomal rearrangement producing a recombinant gene composed of the promoter and first exon of KIR2DL5A fused to KIR3DP1 which was originally thought to be a pseudogene. This leads to the expression in 4.5 percent of a Spanish Caucasoid population of an mRNA which may encode a chimeric protein KIR2DL5A/KIR3DP1.,similarity:Belongs to the immunoglobulin superfamily.,similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains.,similarity:Contains 3 Ig-like C2-type (immunoglobulin-like) domains.,tissue specificity:Expressed in peripheral blood cells.,