U-Blot® CD181 Mouse mAb
Ucallm_WM1864-50
Price range: $268.00 through $328.00
Product details
Background：
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase family. It catalyzes the deacetylation of lysine residues in the histone N-terminal tails and represses transcription in large multiprotein complexes with transcriptional co-repressors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009],
Specifications
| Size | 50μL/100μL |
| Target | IL-8RA |
| Reactivity | Human |
| Applications | FC |
| MW(Calculated) | |
| MW(Observed) | |
| Host Species | Mouse |
| Isotype | Mouse IgG2b/Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | FC:1 µg per million cells in 100 µl volume. For optimal results, the reagent should be titrated according to each specific application |
| Formulation | PBS, pH 7.4 |
| Purification | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography. |
| Storage | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Concentration | 0.5mg/ml |
| Clonality | Monoclonal |
| Clone Number | RMMF0106 |
| Immunogen | The specific immunogen used to produce this antibody is proprietary information. |
| Specificity | Endogenous |
| Gene Name | CXCR1 CMKAR1 IL8RA |
| Protein Name | C-X-C chemokine receptor type 1 (CXC-R1) (CXCR-1) (CDw128a) (High affinity interleukin-8 receptor A) (IL-8R A) (IL-8 receptor type 1) (CD antigen CD181) |
| Other Name | C-X-C chemokine receptor type 1; / CXC-R1; / CXCR-1; / CDw128a; / High affinity interleukin-8 receptor A; / IL-8R A; / IL-8 receptor type 1; / CD antigen CD181 |
| Species | Human |
| Gene ID | 3577 |
| Uniprot | P25024, |
| Species.1 | Mouse |
| Gene ID.1 | 227288 |
| Uniprot.1 | Q810W6 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cell membrane; Multi-pass membrane protein. |
| Tissue Expression | Blood,Placenta, |
| Signaling_pathway | Organismal Systems >> Immune system >> Chemokine signaling pathway;Environmental Information Processing >> Signal transduction >> Phospholipase D signaling pathway;Environmental Information Processing >> Signaling molecules and interaction >> Cytokine-cytokine receptor interaction;Environmental Information Processing >> Signaling molecules and interaction >> Viral protein interaction with cytokine and cytokine receptor |
| Research Areas | >>Cytokine-cytokine receptor interaction; / >>Viral protein interaction with cytokine and cytokine receptor; / >>Chemokine signaling pathway; / >>Phospholipase D signaling pathway; / >>Endocytosis; / >>Epithelial cell signaling in Helicobacter pylori infection |
| Function | Function:Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity.,online information:CXC chemokine receptors entry,similarity:Belongs to the G-protein coupled receptor 1 family., |
Please login to post questions
Related products
