Name: U-Blot® CD183 Mouse mAb
SKU: WM1881
Price: 268 USD
Availability: InStock

U-Blot® CD183 Mouse mAb

Ucallm_WM1881-50

Price range: $268.00 through $328.00

Size

100μl

50μl

Clear

SKU: WM1881-50

Enter the quantity you would like, or drag the panel to find the quantity and price that best for you

Bulk Quote Authorize OEM & ODM

Product details

Background:CD183, also known as CXCR3, is a member of the C-X-C chemokine family, characterized by a pair of cysteine residues separated by a single amino acid. CXCR3 is a 38 kD seven pass transmembrane receptor coupled to G-protein. It mediates Ca2+ mobilization and chemotaxis in response to C-X-C chemokines, such as IP10 (CXCL10), MIG (CXCL9), I-TAC (CXCL11) and PF4 (CXCL4). CXCR3 is expressed primarily on activiated T lymphocytes, NK cells, and some epithelial cells and endothelial cells. It is not expressed on B cells, monocytes, or granulocytes.

Specifications

Size	50μL/100μL
Target	CD183
Reactivity	Human
Applications	IHC, IF
MW(Calculated)
MW(Observed)
Host Species	Mouse
Isotype	Mouse IgG1/Kappa
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	IHC 1:400-1:1000; IF 1:200-1:1000; / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Purification	Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
Clonality	Monoclonal
Clone Number	RMMR1451
Immunogen	The specific immunogen used to produce this antibody is proprietary information.
Specificity	Endogenous
Gene Name	CXCR3 GPR9
Protein Name	C-X-C chemokine receptor type 3
Other Name	CXCR3; / G protein-coupled receptor 9; / GPR9; / CKR-L2; / IP10 receptor; / IP10-R; / Mig receptor; / Mig-R; / C-X-C chemokine receptor type 3 antibody; / CD 183 antibody; / CD182 antibody; / CD183 antibody; / Chemokine; / C X C motif; / receptor 3 antibody; / Chemokine; / C X C; / receptor 3 antibody; / Chemokine CXC Motif Receptor 3 antibody; / CKR L2 antibody; / CKR-L2 antibody; / CKRL2 antibody; / CMKAR3 antibody; / CXC-R3 antibody; / CXCR-3 antibody; / CXCR3 antibody; / CXCR3_HUMAN antibody; / G Protein Coupled Receptor 9 antibody; / G protein-coupled receptor 9 antibody; / GPR9 antibody; / Interferon-inducible protein 10 receptor antibody; / IP-10 receptor antibody; / IP10 antibody; / IP10 R antibody; / IP10 receptor antibody; / IP10-R antibody; / IP10R antibody; / Mig R antibody; / Mig receptor antibody; / Mig-R antibody; / MIGR antibody
Species	Human
Gene ID	2833
Uniprot	P49682,
Species.1	Mouse
Gene ID.1	12766
Uniprot.1	O88410,
Species.2	Rat
Gene ID.2	84475
Uniprot.2	Q9JII9
Cellular Localization	[Isoform 1]: Cell membrane; Multi-pass membrane protein .; [Isoform 2]: Cell membrane; Multi-pass membrane protein .
Tissue Expression	Isoform 1 and isoform 2 are mainly expressed in heart, kidney, liver and skeletal muscle. Isoform 1 is also expressed in placenta. Isoform 2 is expressed in endothelial cells. Expressed in T-cells (at protein level).
Signaling_pathway	Organismal Systems >> Immune system >> Chemokine signaling pathway;Environmental Information Processing >> Signaling molecules and interaction >> Cytokine-cytokine receptor interaction;Environmental Information Processing >> Signaling molecules and interaction >> Viral protein interaction with cytokine and cytokine receptor
Research Areas
Function	Isoform 1 is a Receptor for CXCL9, CXCL10 and CXCL11 and mediates the proliferation of human mesangial cells (HMC).Isoform 2 is a receptor for CXCL4 and also mediates the inhibitory activities of CXCL9, CXCL10 and CXCL11 on the growth of human microvascular endothelial cells (HMVEC). May play a role in angiogenesis. Isoform 3 is mediates the activity of CXCL11.