Price range: $268.00 through $328.00
Background：
This gene encodes a member of the immunoglobulin superfamily. The encoded protein contains a single immunoglobulin (Ig) domain and is a receptor that relays inhibitory signals to suppress the immune response. Alternative splicing results in multiple transcript variants. Polymorphisms in this gene have been associated with an increased risk of rheumatoid arthritis. [provided by RefSeq , Aug 2011] ,
| Size | 50μL/100μL |
| Target | CD272 |
| Reactivity | Mouse |
| Applications | WB, IHC, IF, IP, ELISA |
| MW(Calculated) | 33kD |
| MW(Observed) | 50-70kD |
| Host Species | Rabbit |
| Isotype | IgG,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:200-1:1000; WB 1:10000-1:50000; IF 1:200-1:1000; ELISA 1:5000-1:20000; IP 1:50-1:200; / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Purification | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | RM1649R |
| Immunogen | The specific immunogen used to produce this antibody is proprietary information. |
| Specificity | Endogenous |
| Gene Name | BTLA |
| Protein Name | B- and T-lymphocyte attenuator |
| Other Name | BTLA; / B- and T-lymphocyte attenuator; / B- and T-lymphocyte-associated protein; / CD antigen CD272 |
| Species | Human |
| Gene ID | 151888 |
| Uniprot | Q7Z6A9, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q7TSA3 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein . |
| Tissue Expression | PCR rescued clones,Peripheral blood,Thymus,Trachea, |
| Signaling_pathway | |
| Research Areas | |
| Function | Function:Lymphocyte inhibitory receptor which inhibits lymphocytes during immune response.,PTM:N-glycosylated.,PTM:Phosphorylated on Tyr residues by TNFRSF14 and by antigen receptors cross-linking, both inducing association with PTPN6 and PTPN11.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,subunit:Interacts with tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP-2. Interacts with TNFRSF14/HVEM., |
