Price range: $268.00 through $328.00
Background:The protein encoded by this gene is a plasma membrane protein that catalyzes the conversion of extracellular nucleotides to membrane-permeable nucleosides. The encoded protein is used as a determinant of lymphocyte differentiation. Defects in this gene can lead to the calcification of joints and arteries. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2011],
| Target | CD73 |
| Reactivity | Human |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | 63kD |
| MW(Observed) | 70kD |
| Host Species | Rabbit |
| Isotype | IgG,Kappa |
| Conjugate/Modification | Unmodified |
| Modification | |
| Recommended Dilution Ratio | IHC 1:200-1:1000; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#YS0004) |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Source | |
| Purification | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography. |
| Purity | |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | PT1568R |
| Immunogen | The specific immunogen used to produce this antibody is proprietary information. |
| Sequence | |
| Specificity | Endogenous |
| Gene Name | NT5E |
| Protein Name | 5'-nucleotidase |
| Other Name | NT5E; / NT5; / NTE; / 5'-nucleotidase; / 5'-NT; / Ecto-5'-nucleotidase; / CD73 |
| Species | Human |
| Gene ID-1 | 4907 |
| Uniprot | P21589, |
| Species.1 | Mouse |
| Gene ID-2 | |
| Uniprot.1 | Q61503 |
| Species.2 | |
| Gene ID-3 | |
| Uniprot.2 | |
| Organism-4 | |
| Gene ID-4 | |
| SwissProt-4 | |
| Background | The protein encoded by this gene is a plasma membrane protein that catalyzes the conversion of extracellular nucleotides to membrane-permeable nucleosides. The encoded protein is used as a determinant of lymphocyte differentiation. Defects in this gene can lead to the calcification of joints and arteries. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2011], |
| Cellular Localization | Cell membrane; Lipid-anchor, GPI-anchor . |
| Tissue Expression | Leukocyte,Liver,Placenta,Skin, |
| Signaling_pathway | |
| Research Areas | >>Purine metabolism; / >>Pyrimidine metabolism; / >>Nicotinate and nicotinamide metabolism; / >>Metabolic pathways; / >>Nucleotide metabolism |
| Function | Catalytic activity:A 5'-ribonucleotide + H(2)O = a ribonucleoside + phosphate.,cofactor:Zinc.,Disease:There is a decrease in the activity of NT5 in B-cell chronic lymphocytic leukemia.,Function:Hydrolyzes extracellular nucleotides into membrane permeable nucleosides.,similarity:Belongs to the 5'-nucleotidase family.,subunit:Homodimer; disulfide-linked., |
| RRID |
