Name: U-Blot® CD79b Rabbit mAb
SKU: WR5273
Price: 268 USD
Availability: InStock

U-Blot® CD79b Rabbit mAb

Ucallm_WR5273-50

Price range: $268.00 through $328.00

Size

100μl

50μl

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SKU: WR5273-100

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Product details

Background:The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-beta protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008],

Specifications

Size	50μL/100μL
Target	CD79b
Reactivity	Human, Mouse, Rat
Applications	WB, IHC, IF, IP, ELISA
MW(Calculated)	26kD
MW(Observed)	32-36kD
Host Species	Rabbit
Isotype	IgG,Kappa
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	IHC 1:200-1:1000; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; IP 1:50-1:200; / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Purification	Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
Clonality	Monoclonal
Clone Number	RM1518R
Immunogen	The specific immunogen used to produce this antibody is proprietary information.
Specificity	Endogenous
Gene Name	CD79B
Protein Name	B-cell antigen receptor complex-associated protein beta chain
Other Name	CD79B; / B29; / IGB; / B-cell antigen receptor complex-associated protein beta chain; / B-cell-specific glycoprotein B29; / Ig-beta; / Immunoglobulin-associated B29 protein; / CD79b
Species	Human
Gene ID	974
Uniprot	P40259,
Species.1	Mouse
Gene ID.1
Uniprot.1	P15530
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Cell membrane; Single-pass type I membrane protein. Following antigen binding, the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts. .
Tissue Expression	B-cells.
Signaling_pathway	Organismal Systems >> Immune system >> B cell receptor signaling pathway
Research Areas	>>B cell receptor signaling pathway
Function	Disease:Defects in CD79B are a cause of non-Bruton type agammaglobulinemia [MIM:601495]. Agammaglobulinemia is an immunodeficiency disease which results in developmental defects in the maturation pathway of B-cells.,Function:Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation.,online information:CD79B mutation db,PTM:Phosphorylated on tyrosine upon B-cell activation.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,similarity:Contains 1 ITAM domain.,subcellular location:Following antigen binding, the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts.,subunit:Heterodimer of alpha and beta chains; disulfide-linked. Part of the B-cell antigen receptor complex where the alpha/beta chain heterodimer is non-covalently associated with an antigen-specific membrane-bound surface immunoglobulin of two heavy chains and two light chains.,tissue specificity:B-cells.,