Price range: $268.00 through $328.00
Background：
Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2 (CITED2) Homo sapiens The protein encoded by this gene inhibits transactivation of HIF1A-induced genes by competing with binding of hypoxia-inducible factor 1-alpha to p300-CH1. Mutations in this gene are a cause of cardiac septal defects. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq , May 2012] ,
| Size | 50μL/100μL |
| Target | CITED2 |
| Reactivity | Human, Mouse |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | 28kD |
| MW(Observed) | 29kD |
| Host Species | Rabbit |
| Isotype | IgG,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:200-1:1000; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Purification | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | RM1863R |
| Immunogen | The specific immunogen used to produce this antibody is proprietary information. |
| Specificity | Endogenous |
| Gene Name | CITED2 MRG1 |
| Protein Name | Cbp/p300-interacting transactivator 2 (MSG-related protein 1) (MRG-1) (P35srj) |
| Other Name | |
| Species | Human |
| Gene ID | 10370 |
| Uniprot | Q99967, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | O35740 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Nucleus . Colocalizes with EP300 in dot-like structures. |
| Tissue Expression | Pancreas, |
| Signaling_pathway | Cellular Processes >> Transport and catabolism >> Mitophagy - animal |
| Research Areas | >>Mitophagy - animal |
| Function | Function:Interferes with the binding of transcription factors HIF-1a and STAT2 to p300/CBP.,induction:By hypoxia and deferoxamine.,similarity:Belongs to the CITED family.,subunit:Binds to the p300/CBP CH1 region., |
