U-Blot® CPT2 Rabbit mAb
Ucallm_WR5375-50
Price range: $268.00 through $328.00
Product details
Background:The protein encoded by this gene is a nuclear protein which is transported to the mitochondrial inner membrane. Together with carnitine palmitoyltransferase I, the encoded protein oxidizes long-chain fatty acids in the mitochondria. Defects in this gene are associated with mitochondrial long-chain fatty-acid (LCFA) oxidation disorders. [provided by RefSeq, Jul 2008]
Specifications
| Size | 50μL/100μL |
| Target | CPT2 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | 74kD |
| MW(Observed) | 68kD |
| Host Species | Rabbit |
| Isotype | IgG,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:200-1:1000; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Purification | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | RM1619R |
| Immunogen | The specific immunogen used to produce this antibody is proprietary information. |
| Specificity | Endogenous |
| Gene Name | CPT2 CPT1 |
| Protein Name | Carnitine O-palmitoyltransferase 2, mitochondrial (Carnitine palmitoyltransferase II) (CPT II) |
| Other Name | |
| Species | Human |
| Gene ID | 1376 |
| Uniprot | P23786, |
| Species.1 | Mouse |
| Gene ID.1 | 12896 |
| Uniprot.1 | P52825, |
| Species.2 | Rat |
| Gene ID.2 | 12896 |
| Uniprot.2 | P18886 |
| Cellular Localization | Mitochondrion inner membrane; Peripheral membrane protein; Matrix side. |
| Tissue Expression | Cytoplasmic expression in most tissues. |
| Signaling_pathway | Organismal Systems >> Endocrine system >> PPAR signaling pathway |
| Research Areas | >>Fatty acid degradation; / >>Fatty acid metabolism; / >>PPAR signaling pathway; / >>Thermogenesis; / >>Diabetic cardiomyopathy |
| Function | Involved in the intramitochondrial synthesis of acylcarnitines from accumulated acyl-CoA metabolites (PubMed:20538056, PubMed:24780397). Reconverts acylcarnitines back into the respective acyl-CoA esters that can then undergo beta-oxidation, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion. Active with medium (C8-C12) and long-chain (C14-C18) acyl-CoA esters (PubMed:20538056). |
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