Name: U-Blot® DNA Ligase III Rabbit mAb
SKU: WR5228
Price: 268 USD
Availability: InStock

U-Blot® DNA Ligase III Rabbit mAb

Ucallm_WR5228-50

Price range: $268.00 through $328.00

Size

100μl

50μl

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SKU: WR5228-100

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Product details

Background:This gene is a member of the DNA ligase family. Each member of this family encodes a protein that catalyzes the joining of DNA ends but they each have a distinct role in DNA metabolism. The protein encoded by this gene is involved in excision repair and is located in both the mitochondria and nucleus, with translation initiation from the upstream start codon allowing for transport to the mitochondria and translation initiation from a downstream start codon allowing for transport to the nucleus. Additionally, alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008],

Specifications

Size	50μL/100μL
Target	DNA Ligase III
Reactivity	Human, Mouse, Rat
Applications	WB, IHC, IF, IP, ELISA
MW(Calculated)	113kD
MW(Observed)	102kD
Host Species	Rabbit
Isotype	IgG,Kappa
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	IHC 1:100-1:200; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; IP 1:50-1:200; / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Purification	Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
Clonality	Monoclonal
Clone Number	RM1465R
Immunogen	The specific immunogen used to produce this antibody is proprietary information.
Specificity	Endogenous
Gene Name	LIG3
Protein Name	DNA ligase 3
Other Name	LIG3; / DNA ligase 3; / DNA ligase III; / Polydeoxyribonucleotide synthase [ATP] 3
Species	Human
Gene ID	3980
Uniprot	P49916,
Species.1	Mouse
Gene ID.1
Uniprot.1	P97386
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	[Isoform 1]: Mitochondrion . Contains an N-terminal mitochondrial transit peptide. .; [Isoform 2]: Mitochondrion . Contains an N-terminal mitochondrial transit peptide. .; [Isoform 3]: Nucleus . Lacks the N-terminal mitochondrial transit peptide. .; [Isoform 4]: Nucleus . Lacks the N-terminal mitochondrial transit peptide. .
Tissue Expression	Testis, thymus, prostate and heart.
Signaling_pathway
Research Areas	>>Base excision repair
Function	Catalytic activity:ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).,cofactor:Magnesium.,Function:Interacts with DNA-repair protein XRCC1 and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents.,online information:DNA ligase entry,similarity:Belongs to the ATP-dependent DNA ligase family.,similarity:Contains 1 BRCT domain.,similarity:Contains 1 PARP-type zinc finger.,tissue specificity:Testis, thymus, prostate and heart.,

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U-Blot® DNA Ligase III Rabbit mAb

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U-Blot® DNA Ligase III Rabbit mAb

Product details

Specifications

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