U-Blot® DNAM-1 Rabbit mAb
Ucallm_WR5966-50
Price range: $268.00 through $328.00
Product details
Background：
This gene encodes a glycoprotein expressed on the surface of NK cells , platelets , monocytes and a subset of T cells. It is a member of the Ig-superfamily containing 2 Ig-like domains of the V-set. The protein mediates cellular adhesion of platelets and megakaryocytic cells to vascular endothelial cells. The protein also plays a role in megakaryocytic cell maturation. Alternative splicing results in multiple transcript variants. [provided by RefSeq , Jan 2015] ,
Specifications
| Size | 50μL/100μL |
| Target | DNAM-1 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | 39kD |
| MW(Observed) | 39kD |
| Host Species | Rabbit |
| Isotype | IgG,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:200-1:1000; WB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:5000-1:20000; / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Purification | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | RM1922R |
| Immunogen | The specific immunogen used to produce this antibody is proprietary information. |
| Specificity | Endogenous |
| Gene Name | CD226 |
| Protein Name | CD226 antigen |
| Other Name | CD226; / DNAM1; / CD226 antigen; / DNAX accessory molecule 1; / DNAM-1; / CD antigen CD226 |
| Species | Human |
| Gene ID | 10666 |
| Uniprot | Q15762, |
| Species.1 | Mouse |
| Gene ID.1 | 225825 |
| Uniprot.1 | Q8K4F0 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein . |
| Tissue Expression | Expressed by peripheral blood T-lymphocytes. |
| Signaling_pathway | Environmental Information Processing >> Signaling molecules and interaction >> Cell adhesion molecules |
| Research Areas | >>Cell adhesion molecules |
| Function | Function:Receptor involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-lymphocyte (CTL) and NK cell.,PTM:Phosphorylated.,similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Interacts with PVR and PVRL2.,tissue specificity:Expressed by peripheral blood T-lymphocytes., |
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