Price range: $268.00 through $328.00
Background:Gamma-aminobutyric acid A receptors [GABA(A) receptors] are ligand-gated chloride channels that mediate inhibitory neurotransmission. This gene encodes GABA(A) receptor-associated protein, which is highly positively charged in its N-terminus and shares sequence similarity with light chain-3 of microtubule-associated proteins 1A and 1B. This protein clusters neurotransmitter receptors by mediating interaction with the cytoskeleton. [provided by RefSeq, Jul 2008],
| Size | 50μL/100μL |
| Target | GABARAP+GABARAPL1/2 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | 14kD |
| MW(Observed) | 18kD |
| Host Species | Rabbit |
| Isotype | IgG,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:1000-1:4000; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Purification | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | RM1471R |
| Immunogen | The specific immunogen used to produce this antibody is proprietary information. |
| Specificity | Endogenous |
| Gene Name | GABARAP GABARAPL1 GABARAPL2 |
| Protein Name | Gamma-aminobutyric acid receptor-associated protein; Gamma-aminobutyric acid receptor-associated protein-like 1; Gamma-aminobutyric acid receptor-associated protein-like 2 |
| Other Name | FLC3B,HT004,GEC1,FLC3A,GEF2,GABA(A) receptor-associated protein,GABA(A) receptor-associated protein-like 1,GABA(A) receptor-associated protein-like 2, |
| Species | Human |
| Gene ID | 11337;23710;11345 |
| Uniprot | O95166;Q9H0R8;P60520, |
| Species.1 | Mouse |
| Gene ID.1 | 56486;57436;93739 |
| Uniprot.1 | Q9DCD6;Q8R3R8;P60521, |
| Species.2 | Rat |
| Gene ID.2 | 58974;57436 |
| Uniprot.2 | P60517;Q0VGK0;P60522 |
| Cellular Localization | Cytoplasmic vesicle, autophagosome . Cytoplasmic vesicle membrane; Lipid-anchor . Cytoplasm, cytoskeleton . Endoplasmic reticulum . Golgi apparatus . |
| Tissue Expression | Heart, brain, placenta, liver, skeletal muscle, kidney and pancreas. |
| Signaling_pathway | Cellular Processes >> Transport and catabolism >> Autophagy - animal;Cellular Processes >> Transport and catabolism >> Mitophagy - animal;Organismal Systems >> Immune system >> NOD-like receptor signaling pathway;Environmental Information Processing >> Signal transduction >> FoxO signaling pathway |
| Research Areas | >>FoxO signaling pathway; / >>Autophagy - other; / >>Mitophagy - animal; / >>Autophagy - animal; / >>NOD-like receptor signaling pathway; / >>GABAergic synapse |
| Function | Function:May play a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton.,similarity:Belongs to the MAP1 LC3 family.,subcellular location:Largely associated with intracellular membrane structures including the Golgi apparatus and post-synaptic cisternae. Colocalizes with microtubules.,subunit:Interacts with GPHN and NSF (By similarity). Interacts with GABRG2, beta-tubulin and ULK1.,tissue specificity:Heart, brain, placenta, liver, skeletal muscle, kidney and pancreas., |
