SKU: WR4894 Categories: ,

U-Blot® Granzyme K Rabbit mAb

Price range: $268.00 through $328.00

SKU: WR4894-100
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Product details

Background:This gene product is a member of a group of related serine proteases from the cytoplasmic granules of cytotoxic lymphocytes. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein described here lacks consensus sequences for N-glycosylation present in other granzymes. [provided by RefSeq, Jul 2008],

Specifications

Size50μL/100μL
TargetGranzyme K
ReactivityHuman
ApplicationsWB, IHC, IF, ELISA
MW(Calculated)
MW(Observed)
Host SpeciesRabbit
IsotypeIgG,Kappa
Conjugate/ModificationUnmodified
Recommended Dilution RatioIHC 1:200-1:1000; WB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:5000-1:20000; / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationPBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
PurificationRecombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
ClonalityMonoclonal
Clone NumberRM1067R
ImmunogenThe specific immunogen used to produce this antibody is proprietary information.
SpecificityEndogenous
Gene NameGZMK
Protein NameGranzyme K
Other NameGZMK; / TRYP2; / Granzyme K; / Fragmentin-3; / Granzyme-3; / NK-tryptase-2; / NK-Tryp-2
SpeciesHuman
Gene ID3003
UniprotP49863,
Species.1Mouse
Gene ID.114945
Uniprot.1O35205,
Species.2Rat
Gene ID.229165
Uniprot.2P49864
Cellular LocalizationSecreted. Cytoplasmic granule.
Tissue ExpressionExpressed in lung, spleen, thymus and peripheral blood leukocytes.
Signaling_pathway
Research Areas
Functionsimilarity:Belongs to the peptidase S1 family. Granzyme subfamily.,similarity:Contains 1 peptidase S1 domain.,tissue specificity:Expressed in lung, spleen, thymus and peripheral blood leukocytes.,
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