U-Blot® Histone H3 (Asymmetric Di Methyl Arg8) Rabbit pAb
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Price range: $700.00 through $1,750.00
Product details
Background:Histone H3 is one of the core components of the nucleosome, the basic building block of chromatin. Histones are subject to a variety of chemical modifications, including post-translational modifications of the histone proteins and the methylation of cytosine residues in the DNA. Reported histone modifications include acetylation, methylation, phosphorylation, ubiquitylation, glycosylation, ADP-ribosylation, carbonylation and SUMOylation; these modifications play a major role in regulating gene expression. The methylation of histones can occur on two different residues: arginine or lysine. Histone H3 Arg8, methylated by PRMT enzymes, is involved in nuclear-receptor-mediated transcriptional activation.
Specifications
| Target | Histone H3 |
| Reactivity | Human, Mouse, Wide Range Predicted |
| Application | ChIP,ChIP-Seq,WB,DB |
| MW(Calculated) | |
| MW(Observed) | 17 kDa |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate | Unconjugated |
| Modification | Asymmetric Dimethyl |
| Modification site | Arg8 |
| Recommended dilution ratio | ChIP 10 µl per ChIP; ChIP-Seq 10 µl each; WB 1:500 dilution |
| Formulation | Purified IgG in 70 mM Tris (pH 8), 105 mM NaCl, 31 mM glycine, 0.07 mM EDTA, 30% glycerol and 0.035% sodium azide. |
| Source | |
| Purification | Affinity Purified |
| Purity | |
| Storage | -20°C/2 year. Avoid freeze/thaw cycles. |
| Concentration | |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | This Histone H3 dimethyl Arg8 asymmetric antibody was raised against a peptide containing dimethyl-Arg8 (asymmetric) of human histone H3. |
| Sequence | |
| Specificity | |
| Gene name | |
| Protein name | |
| Alternative name | H3R8me2a |
| Organism-1 | |
| Gene ID‑1 | |
| SwissProt-1 | |
| Organism-2 | |
| Gene ID‑2 | |
| SwissProt-2 | |
| Organism-3 | |
| Gene ID‑3 | |
| SwissProt-3 | |
| Organism-4 | |
| Gene ID‑4 | |
| SwissProt-4 | |
| Cellular Localization | |
| Unnamed: 38 | |
| Unnamed: 39 |
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