U-Blot® Histone H3 (Tri Methyl Lys4, Phospho Thr6) Rabbit pAb
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Price range: $850.00 through $2,125.00
Product details
Background:Histones are basic nuclear proteins that constitute nucleosomes, the fundamental repeating units of eukaryotic chromatin. Combinatorial post‑translational modifications can co‑occur on the same histone H3 N‑terminal tail, generating context‑dependent epigenetic signals. H3K4me3T6p refers to the dual modification of trimethyl‑Lysine 4 and phosphorylated‑Threonine 6 on histone H3. H3K4me3 is deposited by SET/MLL family methyltransferases and marks active gene promoters in interphase. H3T6 phosphorylation is mainly catalyzed by PKC‑family kinases, and is strongly enhanced during mitosis.
Specifications
| Target | Histone H3 |
| Reactivity | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
| Application | ChIP,WB,DB,IHC,IF |
| MW(Calculated) | 15kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | |
| Conjugate | Unconjugated |
| Modification | Tri Methyl, Phospho |
| Modification site | Lys4, Thr6 |
| Recommended dilution ratio | ChIP 2-5 μg/million cells; IHC 1:50; IF 1:50; WB 1:500; DB 1:1,000 |
| Formulation | PBS containing 0.05% azide and 0.05% ProClin 300 |
| Source | |
| Purification | Affinity purified |
| Purity | |
| Storage | Store at -20°C. Avoid freeze/thaw cycles. |
| Concentration | 0.55 μg/μl |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | KLH-conjugated synthetic peptide |
| Sequence | |
| Specificity | |
| Gene name | |
| Protein name | |
| Alternative name | H3K4me3T6p |
| Organism-1 | |
| Gene ID‑1 | |
| SwissProt-1 | |
| Organism-2 | |
| Gene ID‑2 | |
| SwissProt-2 | |
| Organism-3 | |
| Gene ID‑3 | |
| SwissProt-3 | |
| Organism-4 | |
| Gene ID‑4 | |
| SwissProt-4 | |
| Cellular Localization | |
| Unnamed: 38 | |
| Unnamed: 39 |
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