U-Blot® HO-1 Rabbit pAb
Ucallm_WP25049-50
Price range: $268.00 through $328.00
Product details
Background:heme oxygenase 1(HMOX1) Homo sapiens Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family. [provided by RefSeq, Jul 2008],
Specifications
| Size | 50μL/100μL |
| Target | HO1 |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | 33kD |
| MW(Observed) | 33kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:2000-1:10000 |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Purification | The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | |
| Specificity | Endogenous |
| Gene Name | HMOX1 HO HO1 |
| Protein Name | HO-1(Heme Oxygenase 1) |
| Other Name | Heme oxygenase 1 (HO-1) (EC 1.14.99.3) |
| Species | Human |
| Gene ID | 3162 |
| Uniprot | P09601, |
| Species.1 | Mouse |
| Gene ID.1 | 15368 |
| Uniprot.1 | P14901, |
| Species.2 | Rat |
| Gene ID.2 | 24451 |
| Uniprot.2 | P06762 |
| Cellular Localization | Endoplasmic reticulum membrane |
| Tissue Expression | Expressed at higher levels in renal cancer tissue than in normal tissue (at protein level). |
| Signaling_pathway | Cellular Processes >> Cell growth and death >> Ferroptosis;Human Diseases >> Cancer: overview >> Pathways in cancer;Human Diseases >> Cancer: overview >> MicroRNAs in cancer;Human Diseases >> Cancer: specific types >> Hepatocellular carcinoma;Environmental Information Processing >> Signal transduction >> HIF-1 signaling pathway |
| Research Areas | >>Porphyrin metabolism; / >>Metabolic pathways; / >>HIF-1 signaling pathway; / >>Ferroptosis; / >>Mineral absorption; / >>Pathways in cancer; / >>MicroRNAs in cancer; / >>Chemical carcinogenesis - reactive oxygen species; / >>Hepatocellular carcinoma; / >>Fluid shear stress and atherosclerosis |
| Function | Catalytic activity:Heme + 3 AH(2) + 3 O(2) = biliverdin + Fe(2+) + CO + 3 A + 3 H(2)O.,Function:Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed.,induction:Heme oxygenase 1 activity is highly inducible by its substrate heme and by various non-heme substances such as heavy metals, bromobenzene, endotoxin, oxidizing agents and UVA.,similarity:Belongs to the heme oxygenase family., |
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