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Home/Reagents/Antibody/Primary antibody/Monoclonal Antibody/Mouse mAb/U-Blot® CD183 Mouse mAb
SKU: WM1821 Categories: ,

U-Blot® CD183 Mouse mAb

Ucallm_WM1821-50

Price range: $268.00 through $328.00

SKU: WM1821-100
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Product details

Background:OTU deubiquitinase, ubiquitin aldehyde binding 1(OTUB1) Homo sapiens The product of this gene is a member of the OTU (ovarian tumor) superfamily of predicted cysteine proteases. The encoded protein is a highly specific ubiquitin iso-peptidase, and cleaves ubiquitin from branched poly-ubiquitin chains but not from ubiquitinated substrates. It interacts with another ubiquitin protease and an E3 ubiquitin ligase that inhibits cytokine gene transcription in the immune system. It is proposed to function in specific ubiquitin-dependent pathways, possibly by providing an editing function for polyubiquitin chain growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008],

Specifications

Size50μL/100μL
TargetCD183
ReactivityHuman
ApplicationsIHC, IF
MW(Calculated)
MW(Observed)
Host SpeciesMouse
IsotypeMouse IgG1/Kappa
Conjugate/ModificationUnmodified
Recommended Dilution RatioIHC 1:400-1:1000; IF 1:200-1:1000; / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationPBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
PurificationRecombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
ClonalityMonoclonal
Clone NumberRMMR1451
ImmunogenThe specific immunogen used to produce this antibody is proprietary information.
SpecificityEndogenous
Gene NameCXCR3 GPR9
Protein NameC-X-C chemokine receptor type 3
Other NameCXCR3; / G protein-coupled receptor 9; / GPR9; / CKR-L2; / IP10 receptor; / IP10-R; / Mig receptor; / Mig-R; / C-X-C chemokine receptor type 3 antibody; / CD 183 antibody; / CD182 antibody; / CD183 antibody; / Chemokine; / C X C motif; / receptor 3 antibody; / Chemokine; / C X C; / receptor 3 antibody; / Chemokine CXC Motif Receptor 3 antibody; / CKR L2 antibody; / CKR-L2 antibody; / CKRL2 antibody; / CMKAR3 antibody; / CXC-R3 antibody; / CXCR-3 antibody; / CXCR3 antibody; / CXCR3_HUMAN antibody; / G Protein Coupled Receptor 9 antibody; / G protein-coupled receptor 9 antibody; / GPR9 antibody; / Interferon-inducible protein 10 receptor antibody; / IP-10 receptor antibody; / IP10 antibody; / IP10 R antibody; / IP10 receptor antibody; / IP10-R antibody; / IP10R antibody; / Mig R antibody; / Mig receptor antibody; / Mig-R antibody; / MIGR antibody
SpeciesHuman
Gene ID2833
UniprotP49682,
Species.1Mouse
Gene ID.112766
Uniprot.1O88410,
Species.2Rat
Gene ID.284475
Uniprot.2Q9JII9
Cellular Localization[Isoform 1]: Cell membrane; Multi-pass membrane protein .; [Isoform 2]: Cell membrane; Multi-pass membrane protein .
Tissue ExpressionIsoform 1 and isoform 2 are mainly expressed in heart, kidney, liver and skeletal muscle. Isoform 1 is also expressed in placenta. Isoform 2 is expressed in endothelial cells. Expressed in T-cells (at protein level).
Signaling_pathwayOrganismal Systems >> Immune system >> Chemokine signaling pathway;Environmental Information Processing >> Signaling molecules and interaction >> Cytokine-cytokine receptor interaction;Environmental Information Processing >> Signaling molecules and interaction >> Viral protein interaction with cytokine and cytokine receptor
Research Areas
FunctionIsoform 1 is a Receptor for CXCL9, CXCL10 and CXCL11 and mediates the proliferation of human mesangial cells (HMC).Isoform 2 is a receptor for CXCL4 and also mediates the inhibitory activities of CXCL9, CXCL10 and CXCL11 on the growth of human microvascular endothelial cells (HMVEC). May play a role in angiogenesis. Isoform 3 is mediates the activity of CXCL11.
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